Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

Huipin Yuan, Hugo Fernandes, Pamela Habibovic, Jan de Boer, Ana M.C. Barradas, Ad de Ruiter, William R. Walsh, Clemens A. van Blitterswijk, Joost D. de Bruijn

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Abstract

Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of “smart” biomaterials.
Original languageEnglish
Pages (from-to)13614-13619
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number31
DOIs
Publication statusPublished - 2010

Fingerprint

Bone Transplantation
Ceramics
Bone and Bones
Biocompatible Materials
Stem Cells
Elasticity
Cell Differentiation
Sheep
Transplants

Keywords

  • METIS-273557
  • Tricalcium phosphate
  • bone morphogenetic proteins
  • IR-80663
  • Osteoinduction
  • Surface topography
  • Mesenchymal stromal cells

Cite this

Yuan, H., Fernandes, H., Habibovic, P., de Boer, J., Barradas, A. M. C., de Ruiter, A., ... de Bruijn, J. D. (2010). Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13614-13619. https://doi.org/10.1073/pnas.1003600107
Yuan, Huipin ; Fernandes, Hugo ; Habibovic, Pamela ; de Boer, Jan ; Barradas, Ana M.C. ; de Ruiter, Ad ; Walsh, William R. ; van Blitterswijk, Clemens A. ; de Bruijn, Joost D. / Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 31. pp. 13614-13619.
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Yuan, H, Fernandes, H, Habibovic, P, de Boer, J, Barradas, AMC, de Ruiter, A, Walsh, WR, van Blitterswijk, CA & de Bruijn, JD 2010, 'Osteoinductive ceramics as a synthetic alternative to autologous bone grafting' Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 31, pp. 13614-13619. https://doi.org/10.1073/pnas.1003600107

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. / Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M.C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 31, 2010, p. 13614-13619.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

AU - Yuan, Huipin

AU - Fernandes, Hugo

AU - Habibovic, Pamela

AU - de Boer, Jan

AU - Barradas, Ana M.C.

AU - de Ruiter, Ad

AU - Walsh, William R.

AU - van Blitterswijk, Clemens A.

AU - de Bruijn, Joost D.

PY - 2010

Y1 - 2010

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AB - Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of “smart” biomaterials.

KW - METIS-273557

KW - Tricalcium phosphate

KW - bone morphogenetic proteins

KW - IR-80663

KW - Osteoinduction

KW - Surface topography

KW - Mesenchymal stromal cells

U2 - 10.1073/pnas.1003600107

DO - 10.1073/pnas.1003600107

M3 - Article

VL - 107

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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