Resultados de los stents Resolute Integrity y Promus Element en el infarto de miocardio: análisis del ensayo aleatorizado DUTCH PEERS (TWENTE II)

Translated title of the contribution: Outcome After Myocardial Infarction Treated With Resolute Integrity and Promus Element Stents: Insights From the DUTCH PEERS (TWENTE II) Randomized Trial

K. Gert van Houwelingen, Ming Kai Lam, Marije M. Löwik, Peter W. Danse, R. Melvyn Tjon Joe Gin, Gillian A. Jessurun, Rutger L. Anthonio, Hanim Sen, Gerard C.M. Linssen, Maarten J. IJzerman, Carine J.M. Doggen, Clemens von Birgelen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Introduction and objectives: In acute myocardial infarction (MI), novel highly deliverable drug-eluting stents (DES) may be particularly valuable as their flexible stent designs might reduce device-induced traumas to culprit lesions. The aim of the study was to assess the safety and efficacy of percutaneous coronary interventions with 2 novel durable polymer-coated DES in patients with acute MI.

Methods: The prospective, randomized DUTCH PEERS (TWENTE II) multicenter trial compares Resolute Integrity and Promus Element stents in 1811 all-comer patients, of whom 817 (45.1%) were treated for ST-segment elevation MI or non—ST-segment elevation MI and the 2-year outcome is available in 99.9%. The primary clinical endpoint is target vessel failure (TVF), a composite of cardiac death, target vessel related MI, or target vessel revascularization.

Results: Of all 817 patients treated for acute MI, 421 (51.5%) were treated with Resolute Integrity and 396 (48.5%) with Promus Element stents. At the 2-year follow-up, the rates of TVF (7.4% vs 6.1%; P =.45), target lesion revascularization (3.1% vs 2.8%; P =.79), and definite stent thrombosis (1.0% vs 0.5%; P =.69) were low for both stent groups. Consistent with these findings in all patients with acute MI, outcomes for the 2 DES were favorable and similar in both, with 370 patients with ST-segment elevation MI (TVF: 5.1% vs 4.9%; P =.81) and 447 patients with non—ST-segment elevation MI (TVF: 9.0% vs 7.5%; P =.56).

Conclusions:  Resolute Integrity and Promus Element stents were both safe and efficacious in treating patients with acute MI. The present 2-year follow-up data underline the safety of using these devices in this particular clinical setting. Full English text available from:

Original languageSpanish
Pages (from-to)1152-1159
Number of pages8
JournalRevista Espanola de Cardiologia
Issue number12
Publication statusPublished - 1 Dec 2016


  • Acute coronary syndrome
  • Cobalt-chromium zotarolimus-eluting stent
  • Drug-eluting stent
  • Myocardial infarction
  • Percutaneous coronary intervention
  • Platinum-chromium everolimus-eluting stent
  • Promus Element stent
  • Resolute Integrity stent

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