Abstract
In this work we report a method to reduce Taylor dispersion for chromatographic applications by introducing vortices, lateral to the pressure driven flow. We show a fundamental improvement of a reversed-phase chromatographic separation of coumarin 440 and coumarin 480 by inducing vortices in lateral direction, increasing the resolution from 1.3 to 2.05. Since coumarins are relatively fast diffusing molecules, slowly diffusing molecules such as large proteins and other large biomolecules would benefit even more from the displayed technique.
| Original language | English |
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| Title of host publication | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020) |
| Subtitle of host publication | Proceedings of a meeting held 4-9 October 2020, Online |
| Publisher | The Chemical and Biological Microsystems Society |
| Pages | 621-622 |
| Number of pages | 2 |
| ISBN (Print) | 978-1-7334190-1-7, 978-1-7138212-3-6 (Set) |
| Publication status | Published - 2020 |
| Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24 https://microtas2020.org/ |
Conference
| Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 |
|---|---|
| Abbreviated title | MicroTAS 2020 |
| City | Virtual Event |
| Period | 4/10/20 → 9/10/20 |
| Internet address |
Keywords
- AC-electroosmotic flow
- Liquid chromatography
- Taylor dispersion