Overcoming mass transfer limitations by introducing vortex chromatogaphy

Eiko Y. Westerbeek*, Guillermo Gonzalez Amaya, Wouter Olthuis, Jan C.T. Eijkel, Wim de Malsche

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

In this work we report a method to reduce Taylor dispersion for chromatographic applications by introducing vortices, lateral to the pressure driven flow. We show a fundamental improvement of a reversed-phase chromatographic separation of coumarin 440 and coumarin 480 by inducing vortices in lateral direction, increasing the resolution from 1.3 to 2.05. Since coumarins are relatively fast diffusing molecules, slowly diffusing molecules such as large proteins and other large biomolecules would benefit even more from the displayed technique.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherThe Chemical and Biological Microsystems Society
Pages621-622
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event
Duration: 4 Oct 20209 Oct 2020
Conference number: 24
https://microtas2020.org/

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated titleMicroTAS 2020
CityVirtual Event
Period4/10/209/10/20
Internet address

Keywords

  • AC-electroosmotic flow
  • Liquid chromatography
  • Taylor dispersion

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