TY - JOUR
T1 - Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior
AU - Baptista, Danielle
AU - Teixeira, Liliana
AU - van Blitterswijk, Clemens
AU - Giselbrecht, Stefan
AU - Truckenmüller, R.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.
AB - In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.
KW - (I-)BAR domain protein
KW - cell membrane
KW - cell polarity
KW - curvature
KW - in vitro models
KW - microtechnology
UR - http://www.scopus.com/inward/record.url?scp=85062894581&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2019.01.006
DO - 10.1016/j.tibtech.2019.01.006
M3 - Review article
C2 - 30885388
AN - SCOPUS:85062894581
VL - 37
SP - 838
EP - 854
JO - Trends in biotechnology
JF - Trends in biotechnology
SN - 0167-7799
IS - 8
ER -