Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior

Danielle Baptista; Liliana Teixeira; Clemens van Blitterswijk; Stefan Giselbrecht; R. Truckenmüller

doi:10.1016/j.tibtech.2019.01.006

Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior

Danielle Baptista, Liliana Teixeira, Clemens van Blitterswijk, Stefan Giselbrecht, R. Truckenmüller^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

44 Citations (Scopus)

Abstract

In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.

Original language	English
Pages (from-to)	838-854
Number of pages	17
Journal	Trends in biotechnology
Volume	37
Issue number	8
Early online date	16 Mar 2019
DOIs	https://doi.org/10.1016/j.tibtech.2019.01.006
Publication status	Published - 1 Aug 2019

Keywords

(I-)BAR domain protein
cell membrane
cell polarity
curvature
in vitro models
microtechnology

Access to Document

10.1016/j.tibtech.2019.01.006

Cite this

@article{5b4f2c4758c143ec9821bce26ef9e7aa,

title = "Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior",

abstract = "In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.",

keywords = "(I-)BAR domain protein, cell membrane, cell polarity, curvature, in vitro models, microtechnology",

author = "Danielle Baptista and Liliana Teixeira and {van Blitterswijk}, Clemens and Stefan Giselbrecht and R. Truckenm{\"u}ller",

year = "2019",

month = aug,

day = "1",

doi = "10.1016/j.tibtech.2019.01.006",

language = "English",

volume = "37",

pages = "838--854",

journal = "Trends in biotechnology",

issn = "0167-7799",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior

AU - Baptista, Danielle

AU - Teixeira, Liliana

AU - van Blitterswijk, Clemens

AU - Giselbrecht, Stefan

AU - Truckenmüller, R.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.

AB - In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell–material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve readouts of the pure effect of curvature on cells.

KW - (I-)BAR domain protein

KW - cell membrane

KW - cell polarity

KW - curvature

KW - in vitro models

KW - microtechnology

UR - http://www.scopus.com/inward/record.url?scp=85062894581&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2019.01.006

DO - 10.1016/j.tibtech.2019.01.006

M3 - Review article

C2 - 30885388

AN - SCOPUS:85062894581

VL - 37

SP - 838

EP - 854

JO - Trends in biotechnology

JF - Trends in biotechnology

SN - 0167-7799

IS - 8

ER -

Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this