Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Niels G.A. Willemen, Shabir Hassan, Melvin Gurian, Jinghang Li, Iris E. Allijn, Su Ryon Shin*, Jeroen Leijten*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

29 Citations (Scopus)
127 Downloads (Pure)


Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

Original languageEnglish
Pages (from-to)1144-1159
Number of pages16
JournalTrends in biotechnology
Issue number11
Early online date16 Feb 2021
Publication statusPublished - Nov 2021


  • 22/4 OA procedure
  • hypoxia
  • metabolism
  • oxygen generation
  • sustained release
  • biomaterials


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