Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Niels G.A. Willemen; Shabir Hassan; Melvin Gurian; Jinghang Li; Iris E. Allijn; Su Ryon Shin; Jeroen Leijten

doi:10.1016/j.tibtech.2021.01.007

Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Niels G.A. Willemen
, Shabir Hassan
, Melvin Gurian
, Jinghang Li
, Iris E. Allijn
, Su Ryon Shin^*
, Jeroen Leijten^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

129 Citations (Scopus)

669 Downloads (Pure)

Abstract

Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

Original language	English
Pages (from-to)	1144-1159
Number of pages	16
Journal	Trends in biotechnology
Volume	39
Issue number	11
Early online date	16 Feb 2021
DOIs	https://doi.org/10.1016/j.tibtech.2021.01.007
Publication status	Published - Nov 2021

Keywords

22/4 OA procedure
hypoxia
metabolism
oxygen generation
sustained release
biomaterials

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10.1016/j.tibtech.2021.01.007

1-s2.0-S0167779921000135-mainFinal published version, 1.91 MBLicence: Taverne

Cite this

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title = "Oxygen-Releasing Biomaterials: Current Challenges and Future Applications",

abstract = "Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.",

keywords = "22/4 OA procedure, hypoxia, metabolism, oxygen generation, sustained release, biomaterials",

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TY - JOUR

T1 - Oxygen-Releasing Biomaterials

T2 - Current Challenges and Future Applications

AU - Willemen, Niels G.A.

AU - Hassan, Shabir

AU - Gurian, Melvin

AU - Li, Jinghang

AU - Allijn, Iris E.

AU - Ryon Shin, Su

AU - Leijten, Jeroen

N1 - Elsevier deal

PY - 2021/11

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N2 - Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

AB - Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

KW - 22/4 OA procedure

KW - hypoxia

KW - metabolism

KW - oxygen generation

KW - sustained release

KW - biomaterials

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DO - 10.1016/j.tibtech.2021.01.007

M3 - Review article

AN - SCOPUS:85101352322

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VL - 39

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EP - 1159

JO - Trends in biotechnology

JF - Trends in biotechnology

IS - 11

ER -

Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

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Keywords

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