Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of a novel Am(III)-selective extractants

N. Nikishkin; Jurriaan Huskens; J. Assenmacher; A. Wilden; G. Modolo; Willem Verboom

doi:10.1039/c2ob25787d

Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of a novel Am(III)-selective extractants

N. Nikishkin, Jurriaan Huskens, J. Assenmacher, A. Wilden, G. Modolo, Willem Verboom

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration

Original language	Undefined
Pages (from-to)	5443-5451
Number of pages	8
Journal	Organic & biomolecular chemistry
Volume	10
Issue number	28
DOIs	https://doi.org/10.1039/c2ob25787d
Publication status	Published - 2012

Keywords

METIS-293806
IR-85051

Access to Document

10.1039/c2ob25787d

Cite this

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abstract = "Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration",

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doi = "10.1039/c2ob25787d",

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T1 - Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of a novel Am(III)-selective extractants

AU - Nikishkin, N.

AU - Huskens, Jurriaan

AU - Assenmacher, J.

AU - Wilden, A.

AU - Modolo, G.

AU - Verboom, Willem

PY - 2012

Y1 - 2012

N2 - Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration

AB - Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration

KW - METIS-293806

KW - IR-85051

U2 - 10.1039/c2ob25787d

DO - 10.1039/c2ob25787d

M3 - Article

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VL - 10

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