Palladium-catalyzed cross-coupling of various phosphorus pronucleophiles with chloropyrazines: synthesis of a novel Am(III)-selective extractants

N. Nikishkin, Jurriaan Huskens, J. Assenmacher, A. Wilden, G. Modolo, Willem Verboom

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Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81–95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selectivity for Am3+ over Eu3+ with separation factors up to 40 at pH 1 at 0.01 mol L−1 ligand concentration
Original languageUndefined
Pages (from-to)5443-5451
Number of pages8
JournalOrganic & biomolecular chemistry
Issue number28
Publication statusPublished - 2012


  • METIS-293806
  • IR-85051

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