Parametric array technique for microbubble excitation

Henk Vos, David E. Goertz, Antonius F.W. van der Steen, N. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


This study investigates the use of an acoustic parametric array as a means for microbubble excitation. The excitation wave is generated during propagation in a nonlinear medium of two high-frequency carrier waves, whereby the frequency of the excitation wave is the difference frequency of the carrier waves. Carrier waves of around 10 and 25 MHz are used to generate low-frequency waves between 0.5 and 3.5 MHz at amplitudes in the range of 25 to 80 kPa in water. We demonstrate with high-speed camera observations that it is possible to induce microbubble oscillations with the low frequency signal arising from the nonlinear propagation process. As an application, we determined the resonance frequency of Definity contrast agent microbubbles with radius ranging from 1.5 to 5 μm by sweeping the difference frequency in the range from 0.5 to 3.5 MHz.
Original languageEnglish
Pages (from-to)924-934
Number of pages11
JournalIEEE transactions on ultrasonics, ferroelectrics and frequency control
Issue number5
Publication statusPublished - 2011


  • nonlinear medium
  • high-frequency carrier waves
  • microbubble excitation
  • microbubble oscillations
  • ultrasound pulse
  • METIS-278167
  • IR-79176
  • acoustic parametric array
  • frequency 0.5 MHz to 3.5 MHz
  • excitation wave propagation


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