Particle Size Determination in Impedance Flow Cytometry Using Measured Opacity

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    Abstract

    Microfluidic electrical flow cytometry is a popular method to study a wide variety of biological cell properties. Unfortunately, when using coplanar electrodes, this method is sensitive to positional differences of passing particles or cells. In this work we present a novel compensation method to account for the particle position in a coplanar electrode setup using the measured electrical opacity. We demonstrate an accurate size discrimination of 5, 6 and 7 m polystyrene beads irrespective of their position using the measured electrical opacity making use of the variation of electrical field strength with height in the channel. Thus, only two electrodes are required, which is favorable for microfluidic devices with size limitations.

    Original languageEnglish
    Title of host publication21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
    Place of PublicationPiscataway, NJ
    PublisherIEEE
    Pages1036-1039
    Number of pages4
    ISBN (Electronic)978-1-6654-1267-4
    ISBN (Print)978-1-6654-1267-4, 978-1-6654-4845-1
    DOIs
    Publication statusPublished - 20 Jun 2021
    Event21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, United States
    Duration: 20 Jun 202125 Jun 2021
    Conference number: 21

    Publication series

    NameInternational Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)
    PublisherIEEE
    Volume2021
    ISSN (Print)2167-0013
    ISSN (Electronic)2167-0021

    Conference

    Conference21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
    Abbreviated titleTransducers 2021
    CountryUnited States
    CityVirtual, Online
    Period20/06/2125/06/21

    Keywords

    • Coplanar electrodes
    • Electrical opacity
    • Flow cytometry
    • Microfluidics
    • Size determination

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