Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry

Babu Varghese*, Vinayakrishnan Rajan, Ton G. Van Leeuwen, Wiendelt Steenbergen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
11 Downloads (Pure)

Abstract

In optical Doppler measurements, the path length of the light is unknown. To facilitate quantitative measurements, we develop a phase-modulated Mach-Zehnder interferometer with separate fibers for illumination and detection. With this setup, path-length-resolved dynamic light scattering measurements of multiple scattered light in static and dynamic turbid media are performed. Optical path length distributions spanning a range from 0 to11mm are measured from the area under the phase modulation peak around the modulation frequency in the power spectrum. A Doppler-broadened phase modulation interference peak is observed that shows an increase in the average Doppler shift with optical path length, independent of absorption. Validation of the estimated path length distributions is done by measuring their deformation for increasing absorption and comparing these observations with predictions based on Lambert-Beer's law.

Original languageEnglish
Article number024020
JournalJournal of biomedical optics
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Mar 2007

Fingerprint

Interferometry
interferometry
Photons
Phase modulation
photons
optical paths
phase modulation
Mach-Zehnder interferometers
Doppler effect
Frequency modulation
Dynamic light scattering
Power spectrum
Beer law
Lighting
frequency modulation
power spectra
light scattering
Fibers
illumination
interference

Keywords

  • Doppler
  • Light
  • Mach-Zehnder interferometer
  • Phase modulation
  • Turbid media

Cite this

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title = "Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry",
abstract = "In optical Doppler measurements, the path length of the light is unknown. To facilitate quantitative measurements, we develop a phase-modulated Mach-Zehnder interferometer with separate fibers for illumination and detection. With this setup, path-length-resolved dynamic light scattering measurements of multiple scattered light in static and dynamic turbid media are performed. Optical path length distributions spanning a range from 0 to11mm are measured from the area under the phase modulation peak around the modulation frequency in the power spectrum. A Doppler-broadened phase modulation interference peak is observed that shows an increase in the average Doppler shift with optical path length, independent of absorption. Validation of the estimated path length distributions is done by measuring their deformation for increasing absorption and comparing these observations with predictions based on Lambert-Beer's law.",
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Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry. / Varghese, Babu; Rajan, Vinayakrishnan; Van Leeuwen, Ton G.; Steenbergen, Wiendelt.

In: Journal of biomedical optics, Vol. 12, No. 2, 024020, 01.03.2007.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry

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AU - Rajan, Vinayakrishnan

AU - Van Leeuwen, Ton G.

AU - Steenbergen, Wiendelt

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AB - In optical Doppler measurements, the path length of the light is unknown. To facilitate quantitative measurements, we develop a phase-modulated Mach-Zehnder interferometer with separate fibers for illumination and detection. With this setup, path-length-resolved dynamic light scattering measurements of multiple scattered light in static and dynamic turbid media are performed. Optical path length distributions spanning a range from 0 to11mm are measured from the area under the phase modulation peak around the modulation frequency in the power spectrum. A Doppler-broadened phase modulation interference peak is observed that shows an increase in the average Doppler shift with optical path length, independent of absorption. Validation of the estimated path length distributions is done by measuring their deformation for increasing absorption and comparing these observations with predictions based on Lambert-Beer's law.

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