Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry

Babu Varghese*, Vinayakrishnan Rajan, Ton G. Van Leeuwen, Wiendelt Steenbergen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
25 Downloads (Pure)

Abstract

In optical Doppler measurements, the path length of the light is unknown. To facilitate quantitative measurements, we develop a phase-modulated Mach-Zehnder interferometer with separate fibers for illumination and detection. With this setup, path-length-resolved dynamic light scattering measurements of multiple scattered light in static and dynamic turbid media are performed. Optical path length distributions spanning a range from 0 to11mm are measured from the area under the phase modulation peak around the modulation frequency in the power spectrum. A Doppler-broadened phase modulation interference peak is observed that shows an increase in the average Doppler shift with optical path length, independent of absorption. Validation of the estimated path length distributions is done by measuring their deformation for increasing absorption and comparing these observations with predictions based on Lambert-Beer's law.

Original languageEnglish
Article number024020
JournalJournal of biomedical optics
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Mar 2007

Keywords

  • Doppler
  • Light
  • Mach-Zehnder interferometer
  • Phase modulation
  • Turbid media

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