PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation

C. Hiemstra; W.E. Hennink; Zhiyuan Zhong; J. Feijen; T Sam; X. Jiang; Pieter J. Dijkstra; Jan Feijen

doi:10.1016/j.jconrel.2006.09.027

PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation

C. Hiemstra, W.E. Hennink (Editor), Zhiyuan Zhong, J. Feijen (Editor), T Sam (Editor), X. Jiang, Pieter J. Dijkstra, Jan Feijen

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Abstract

Water-soluble PEG–PLLA and PEG–PDLA multiblock copolymers were synthesized and investigated for in situ hydrogel formation by stereocomplexation between the PLLA and PDLA blocks. The critical gel concentration measurements showed that these multiblock copolymers are able to form stereocomplexed hydrogels at a much lower concentration in water than the parent triblock copolymers. Furthermore, rheology studies showed significantly improved mechanical properties of the multiblock copolymer stereocomplexed hydrogels compared to the triblock copolymer hydrogels, obtained under otherwise same conditions.

Original language	Undefined
Pages	17-19
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.027
Publication status	Published - 5 Apr 2006
Event	9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands Duration: 5 Apr 2006 → 7 Apr 2006 Conference number: 9

Conference

Conference	9th European Symposium on Controlled Drug Delivery, ESCDD 2006
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	5/04/06 → 7/04/06

Keywords

METIS-236891
IR-71110

Access to Document

10.1016/j.jconrel.2006.09.027

Cite this

Hiemstra, C., Hennink, W. E. (Ed.), Zhong, Z., Feijen, J. (Ed.), Sam, T. (Ed.), Jiang, X., Dijkstra, P. J., & Feijen, J. (2006). PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation. 17-19. Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2006.09.027

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title = "PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation",

abstract = "Water-soluble PEG–PLLA and PEG–PDLA multiblock copolymers were synthesized and investigated for in situ hydrogel formation by stereocomplexation between the PLLA and PDLA blocks. The critical gel concentration measurements showed that these multiblock copolymers are able to form stereocomplexed hydrogels at a much lower concentration in water than the parent triblock copolymers. Furthermore, rheology studies showed significantly improved mechanical properties of the multiblock copolymer stereocomplexed hydrogels compared to the triblock copolymer hydrogels, obtained under otherwise same conditions.",

keywords = "METIS-236891, IR-71110",

author = "C. Hiemstra and W.E. Hennink and Zhiyuan Zhong and J. Feijen and T Sam and X. Jiang and Dijkstra, {Pieter J.} and Jan Feijen",

note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ; null ; Conference date: 05-04-2006 Through 07-04-2006",

year = "2006",

month = apr,

day = "5",

doi = "10.1016/j.jconrel.2006.09.027",

language = "Undefined",

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Hiemstra, C, Hennink, WE (ed.), Zhong, Z, Feijen, J (ed.), Sam, T (ed.), Jiang, X, Dijkstra, PJ & Feijen, J 2006, 'PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation', Paper presented at 9th European Symposium on Controlled Drug Delivery, ESCDD 2006, Noordwijk aan Zee, Netherlands, 5/04/06 - 7/04/06 pp. 17-19. https://doi.org/10.1016/j.jconrel.2006.09.027

TY - CONF

T1 - PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation

AU - Hiemstra, C.

AU - Zhong, Zhiyuan

AU - Jiang, X.

AU - Dijkstra, Pieter J.

AU - Feijen, Jan

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, T

N1 - Conference code: 9

PY - 2006/4/5

Y1 - 2006/4/5

N2 - Water-soluble PEG–PLLA and PEG–PDLA multiblock copolymers were synthesized and investigated for in situ hydrogel formation by stereocomplexation between the PLLA and PDLA blocks. The critical gel concentration measurements showed that these multiblock copolymers are able to form stereocomplexed hydrogels at a much lower concentration in water than the parent triblock copolymers. Furthermore, rheology studies showed significantly improved mechanical properties of the multiblock copolymer stereocomplexed hydrogels compared to the triblock copolymer hydrogels, obtained under otherwise same conditions.

AB - Water-soluble PEG–PLLA and PEG–PDLA multiblock copolymers were synthesized and investigated for in situ hydrogel formation by stereocomplexation between the PLLA and PDLA blocks. The critical gel concentration measurements showed that these multiblock copolymers are able to form stereocomplexed hydrogels at a much lower concentration in water than the parent triblock copolymers. Furthermore, rheology studies showed significantly improved mechanical properties of the multiblock copolymer stereocomplexed hydrogels compared to the triblock copolymer hydrogels, obtained under otherwise same conditions.

KW - METIS-236891

KW - IR-71110

U2 - 10.1016/j.jconrel.2006.09.027

DO - 10.1016/j.jconrel.2006.09.027

M3 - Paper

SP - 17

EP - 19

Y2 - 5 April 2006 through 7 April 2006

ER -