PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Bram Zoetebier, A. Sohrabi, B. Lou, Mark A. Hempenius, W.E. Hennink, Gyula J. Vancso

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)
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Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.
Original languageEnglish
Pages (from-to)7707-7710
JournalChemical communications
Volume52
Issue number49
DOIs
Publication statusPublished - 2016

Keywords

  • IR-101401
  • METIS-317910

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