PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Bram Zoetebier; A. Sohrabi; B. Lou; Mark A. Hempenius; W.E. Hennink; Gyula J. Vancso

doi:10.1039/C6CC02733D

PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Bram Zoetebier, A. Sohrabi, B. Lou, Mark A. Hempenius, W.E. Hennink, Gyula J. Vancso

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Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

Original language	English
Pages (from-to)	7707-7710
Journal	Chemical communications
Volume	52
Issue number	49
DOIs	https://doi.org/10.1039/C6CC02733D
Publication status	Published - 2016

Keywords

IR-101401
METIS-317910
22/4 OA procedure

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10.1039/C6CC02733D

c6cc02733d1Final published version, 812 KBLicence: Taverne
c6cc02733dFinal published version, 1.6 MBLicence: Taverne

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title = "PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery",

abstract = "Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.",

keywords = "IR-101401, METIS-317910, 22/4 OA procedure",

author = "Bram Zoetebier and A. Sohrabi and B. Lou and Hempenius, {Mark A.} and W.E. Hennink and Vancso, {Gyula J.}",

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language = "English",

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T1 - PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

AU - Zoetebier, Bram

AU - Sohrabi, A.

AU - Lou, B.

AU - Hempenius, Mark A.

AU - Hennink, W.E.

AU - Vancso, Gyula J.

PY - 2016

Y1 - 2016

N2 - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

AB - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

KW - IR-101401

KW - METIS-317910

KW - 22/4 OA procedure

U2 - 10.1039/C6CC02733D

DO - 10.1039/C6CC02733D

M3 - Article

SN - 1359-7345

VL - 52

SP - 7707

EP - 7710

JO - Chemical communications

JF - Chemical communications

IS - 49

ER -

PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Abstract

Keywords

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