PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Bram Zoetebier; A. Sohrabi; B. Lou; Mark A. Hempenius; W.E. Hennink; Gyula J. Vancso

doi:10.1039/C6CC02733D

PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Bram Zoetebier
, A. Sohrabi
, B. Lou
, Mark A. Hempenius
, W.E. Hennink
, Gyula J. Vancso

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

217 Downloads (Pure)

Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

Original language	English
Pages (from-to)	7707-7710
Journal	Chemical communications
Volume	52
Issue number	49
DOIs	https://doi.org/10.1039/C6CC02733D
Publication status	Published - 2016

Keywords

IR-101401
METIS-317910
22/4 OA procedure

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10.1039/C6CC02733D

c6cc02733d1Final published version, 812 KBLicence: Taverne
c6cc02733dFinal published version, 1.6 MBLicence: Taverne

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title = "PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery",

abstract = "Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.",

keywords = "IR-101401, METIS-317910, 22/4 OA procedure",

author = "Bram Zoetebier and A. Sohrabi and B. Lou and Hempenius, \{Mark A.\} and W.E. Hennink and Vancso, \{Gyula J.\}",

year = "2016",

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language = "English",

volume = "52",

pages = "7707--7710",

journal = "Chemical communications",

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publisher = "Royal Society of Chemistry",

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T1 - PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

AU - Zoetebier, Bram

AU - Sohrabi, A.

AU - Lou, B.

AU - Hempenius, Mark A.

AU - Hennink, W.E.

AU - Vancso, Gyula J.

PY - 2016

Y1 - 2016

N2 - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

AB - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

KW - IR-101401

KW - METIS-317910

KW - 22/4 OA procedure

U2 - 10.1039/C6CC02733D

DO - 10.1039/C6CC02733D

M3 - Article

SN - 1359-7345

VL - 52

SP - 7707

EP - 7710

JO - Chemical communications

JF - Chemical communications

IS - 49

ER -

PEG stabilized DNA – poly(ferrocenylsilane) polyplexes for gene delivery

Abstract

Keywords

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