Performance of a highly sensitive optical waveguide Mach-Zehnder interferometer immunosensor

R.G. Heideman, R.P.H. Kooyman, J. Greve

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Abstract

We describe a highly sensitive sensor which uses the evanescent field of a reusable planar optical waveguide as the sensing element. The waveguide used is optimized to obtain a steep dependence of the propagation velocity on the refractive-index profile near the surface. The adsorption of a layer of proteins thus results in a phase change, which is measured interferometrically using a Mach-Zehnder interferometer set-up. The stability of the interferometer is such that phase changes = (1 × 10-2)2pi per hour can be measured. Immunoreactions have been monitored down to concentrations of 5 × 10-11 M of a 40 kDa protein.
Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalSensors and Actuators B: Chemical
Volume10
Issue number3
DOIs
Publication statusPublished - 1993

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