Performance of integrated optical microcavities for refractive index and fluorescence sensing

E. Krioukov; Jan Greve; Cornelis Otto

doi:10.1016/S0925-4005(03)00022-4

Performance of integrated optical microcavities for refractive index and fluorescence sensing

E. Krioukov, Jan Greve, Cornelis Otto

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

8 Downloads (Pure)

Abstract

The performance of a novel sensor based on an integrated optical (IO) disk microcavity (MC) is theoretically studied. The MC is a resonant waveguide structure in which multiple interference of a guided mode occurs. At resonance, the MC is extremely sensitive to refractive index changes and it sustains locally enhanced optical field. Therefore, the MC is naturally suitable as an extremely responsive sensor for measuring minute changes in refractive index and/or fluorescence of an analyte. Combination of multiple interference and extremely small sampling volume (few femtoliters) provides unique sensitivity of the MC device. A factor of 9 increase in fluorescence sensitivity versus waveguide sensor is anticipated. Provided shot-noise limited detection, the refractive index resolution down to 10−9 is feasible with the MC sensor, which exceeds that of the straight waveguide interferometer by the order of magnitude. MC-sensors can be combined into arrays providing high throughput detection of both labeled and non-fluorescent biological species.

Original language	Undefined
Pages (from-to)	58-67
Number of pages	9
Journal	Sensors and actuators
Volume	B90
Issue number	1-3
DOIs	https://doi.org/10.1016/S0925-4005(03)00022-4
Publication status	Published - 2003

Keywords

Waveguides
Optical disk microcavity
Microfluidic
IR-74971
METIS-211681

Access to Document

10.1016/S0925-4005(03)00022-4

Cite this

@article{089957db6ab34b679bc018adc6cac9e3,

title = "Performance of integrated optical microcavities for refractive index and fluorescence sensing",

abstract = "The performance of a novel sensor based on an integrated optical (IO) disk microcavity (MC) is theoretically studied. The MC is a resonant waveguide structure in which multiple interference of a guided mode occurs. At resonance, the MC is extremely sensitive to refractive index changes and it sustains locally enhanced optical field. Therefore, the MC is naturally suitable as an extremely responsive sensor for measuring minute changes in refractive index and/or fluorescence of an analyte. Combination of multiple interference and extremely small sampling volume (few femtoliters) provides unique sensitivity of the MC device. A factor of 9 increase in fluorescence sensitivity versus waveguide sensor is anticipated. Provided shot-noise limited detection, the refractive index resolution down to 10−9 is feasible with the MC sensor, which exceeds that of the straight waveguide interferometer by the order of magnitude. MC-sensors can be combined into arrays providing high throughput detection of both labeled and non-fluorescent biological species.",

keywords = "Waveguides, Optical disk microcavity, Microfluidic, IR-74971, METIS-211681",

author = "E. Krioukov and Jan Greve and Cornelis Otto",

note = "Proceedings of the 6th European Conference on Optical Chemical Sensors and Biosensors EUROPT(R)ODE VI, Manchester, UK, 7 April 2003 ",

year = "2003",

doi = "10.1016/S0925-4005(03)00022-4",

language = "Undefined",

volume = "B90",

pages = "58--67",

journal = "Sensors and actuators",

issn = "0250-6874",

publisher = "Elsevier B.V.",

number = "1-3",

}

TY - JOUR

T1 - Performance of integrated optical microcavities for refractive index and fluorescence sensing

AU - Krioukov, E.

AU - Greve, Jan

AU - Otto, Cornelis

N1 - Proceedings of the 6th European Conference on Optical Chemical Sensors and Biosensors EUROPT(R)ODE VI, Manchester, UK, 7 April 2003

PY - 2003

Y1 - 2003

N2 - The performance of a novel sensor based on an integrated optical (IO) disk microcavity (MC) is theoretically studied. The MC is a resonant waveguide structure in which multiple interference of a guided mode occurs. At resonance, the MC is extremely sensitive to refractive index changes and it sustains locally enhanced optical field. Therefore, the MC is naturally suitable as an extremely responsive sensor for measuring minute changes in refractive index and/or fluorescence of an analyte. Combination of multiple interference and extremely small sampling volume (few femtoliters) provides unique sensitivity of the MC device. A factor of 9 increase in fluorescence sensitivity versus waveguide sensor is anticipated. Provided shot-noise limited detection, the refractive index resolution down to 10−9 is feasible with the MC sensor, which exceeds that of the straight waveguide interferometer by the order of magnitude. MC-sensors can be combined into arrays providing high throughput detection of both labeled and non-fluorescent biological species.

AB - The performance of a novel sensor based on an integrated optical (IO) disk microcavity (MC) is theoretically studied. The MC is a resonant waveguide structure in which multiple interference of a guided mode occurs. At resonance, the MC is extremely sensitive to refractive index changes and it sustains locally enhanced optical field. Therefore, the MC is naturally suitable as an extremely responsive sensor for measuring minute changes in refractive index and/or fluorescence of an analyte. Combination of multiple interference and extremely small sampling volume (few femtoliters) provides unique sensitivity of the MC device. A factor of 9 increase in fluorescence sensitivity versus waveguide sensor is anticipated. Provided shot-noise limited detection, the refractive index resolution down to 10−9 is feasible with the MC sensor, which exceeds that of the straight waveguide interferometer by the order of magnitude. MC-sensors can be combined into arrays providing high throughput detection of both labeled and non-fluorescent biological species.

KW - Waveguides

KW - Optical disk microcavity

KW - Microfluidic

KW - IR-74971

KW - METIS-211681

U2 - 10.1016/S0925-4005(03)00022-4

DO - 10.1016/S0925-4005(03)00022-4

M3 - Article

SN - 0250-6874

VL - B90

SP - 58

EP - 67

JO - Sensors and actuators

JF - Sensors and actuators

IS - 1-3

ER -