TY - JOUR
T1 - Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions
AU - Schaap, Mirjam J.
AU - Chizari, Ata
AU - Knop, Tom
AU - Groenewoud, Hans M.M.
AU - van Erp, Piet E.J.
AU - de Jong, Elke M.G.J.
AU - Steenbergen, Wiendelt
AU - Seyger, Marieke M.B.
N1 - Funding Information:
We would like to thank Tjitske Bannink and Freek Bielevelt for their valuable help during the implementation of the HAPI system. This study was funded by NWO Domain Applied and Engineering Sciences (AES) under grant number 14538.
Publisher Copyright:
© 2021 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Background: Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion in large body areas using laser speckle contrast imaging (LSCI). Objectives: To (i) assess whether increased perilesional perfusion and perfusion inhomogeneity are predictors for expansion of psoriasis lesions and (ii) assess feasibility of the HAPI system in a mounted modality. Methods: In this interventional pilot study in adults with unstable plaque psoriasis, HAPI measurements and color photographs were performed for lesions present on one body region at week 0, 2, 4, 6 and 8. The presence of increased perilesional perfusion and perfusion inhomogeneity was determined. Clinical outcome was categorized as increased, stable or decreased lesion surface between visits. Patient feedback was collected on a 10-point scale. Results: In total, 110 lesions with a median follow-up of 6 (IQR 6.0) weeks were assessed in 6 patients with unstable plaque psoriasis. Perfusion data was matched to 281 clinical outcomes after two weeks. A mixed multinomial logistic regression model revealed a predictive value of perilesional increased perfusion (OR 9.90; p < 0.001) and perfusion inhomogeneity (OR 2.39; p = 0.027) on lesion expansion after two weeks compared to lesion stability. HAPI measurements were considered fast, patient-friendly and important by patients. Conclusion: Visualization of increased perilesional perfusion and perfusion inhomogeneity by noninvasive whole field LSCI holds potential for prediction of psoriatic lesion expansion. Furthermore, the HAPI is a feasible and patient-friendly tool.
AB - Background: Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion in large body areas using laser speckle contrast imaging (LSCI). Objectives: To (i) assess whether increased perilesional perfusion and perfusion inhomogeneity are predictors for expansion of psoriasis lesions and (ii) assess feasibility of the HAPI system in a mounted modality. Methods: In this interventional pilot study in adults with unstable plaque psoriasis, HAPI measurements and color photographs were performed for lesions present on one body region at week 0, 2, 4, 6 and 8. The presence of increased perilesional perfusion and perfusion inhomogeneity was determined. Clinical outcome was categorized as increased, stable or decreased lesion surface between visits. Patient feedback was collected on a 10-point scale. Results: In total, 110 lesions with a median follow-up of 6 (IQR 6.0) weeks were assessed in 6 patients with unstable plaque psoriasis. Perfusion data was matched to 281 clinical outcomes after two weeks. A mixed multinomial logistic regression model revealed a predictive value of perilesional increased perfusion (OR 9.90; p < 0.001) and perfusion inhomogeneity (OR 2.39; p = 0.027) on lesion expansion after two weeks compared to lesion stability. HAPI measurements were considered fast, patient-friendly and important by patients. Conclusion: Visualization of increased perilesional perfusion and perfusion inhomogeneity by noninvasive whole field LSCI holds potential for prediction of psoriatic lesion expansion. Furthermore, the HAPI is a feasible and patient-friendly tool.
KW - angiogenesis
KW - disease stability
KW - inflammatory skin disease
KW - LSCI
KW - microvasculature
UR - http://www.scopus.com/inward/record.url?scp=85116464957&partnerID=8YFLogxK
U2 - 10.1111/srt.13098
DO - 10.1111/srt.13098
M3 - Article
AN - SCOPUS:85116464957
SN - 0909-752X
VL - 28
SP - 104
EP - 110
JO - Skin research and technology
JF - Skin research and technology
IS - 1
ER -