Perfusion territory imaging of intracranial branching arteries: Optimization of continuous artery-selective spin labeling (CASSL)

Michael Helle*, Susanne Rüfer, Karsten Alfke, Olav Jansen, David G. Norris

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Continuous artery-selective spin labeling (CASSL) is based on a standard continuous arterial spin labeling sequence with adiabatic flow-driven inversion and an amplitude-modulated control experiment, and has been proposed recently as a new method for the noninvasive flow territory mapping of cerebral arteries. Spatial selectivity is achieved by the rotation of a tilted labeling plane about the axis of a selected artery, which restricts the tagging pulses to the same spatial position for the vessel of interest but, for any other adjacent and parallel artery, the locus of resonance will vary in time and saturates the blood at a certain distance to the labeling focus. In numerical simulations and in a volunteer study, the key labeling parameters of CASSL were investigated with the goal of increasing the spatial selectivity whilst maintaining sufficient labeling efficiency, in order to selectively label the blood in small intracranial arteries distal to the circle of Willis. The optimized labeling parameters were employed in vivo and adapted to different vascular geometries. The labeling of small intracranial branches of the anterior, middle and posterior cerebral arteries in close vicinity to other vessels yielded clearly delineated perfusion territories and demonstrated the method's capability for highly selective perfusion measurements.

Original languageEnglish
Pages (from-to)404-412
Number of pages9
JournalNMR in biomedicine
Volume24
Issue number4
Early online date8 Nov 2010
DOIs
Publication statusPublished - May 2011
Externally publishedYes

Keywords

  • Arterial spin labeling
  • Cerebrovascular disease
  • Perfusion territories
  • n/a OA procedure

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