Personalized nanomedicine

Twan Gerardus Gertudis Maria Lammers, L.Y. Rizzo, Gerrit Storm, F. Kiessling

Research output: Contribution to journalArticleAcademicpeer-review

153 Citations (Scopus)


Abstract Personalized medicine aims to individualize chemotherapeutic interventions on the basis of ex vivo and in vivo information on patient- and disease-specific characteristics. By noninvasively visualizing how well image-guided nanomedicines-that is, submicrometer-sized drug delivery systems containing both drugs and imaging agents within a single formulation, and designed to more specifically deliver drug molecules to pathologic sites-accumulate at the target site, patients likely to respond to nanomedicine-based therapeutic interventions may be preselected. In addition, by longitudinally monitoring how well patients respond to nanomedicine-based therapeutic interventions, drug doses and treatment protocols can be individualized and optimized during follow-up. Furthermore, noninvasive imaging information on the accumulation of nanomedicine formulations in potentially endangered healthy tissues may be used to exclude patients from further treatment. Consequently, combining noninvasive imaging with tumor-targeted drug delivery seems to hold significant potential for personalizing nanomedicine-based chemotherapeutic interventions, to achieve delivery of the right drug to the right location in the right patient at the right time.
Original languageEnglish
Pages (from-to)4889-4894
JournalClinical cancer research
Issue number18
Publication statusPublished - 2012


  • METIS-292680
  • IR-83085


Dive into the research topics of 'Personalized nanomedicine'. Together they form a unique fingerprint.

Cite this