TY - JOUR
T1 - PET/CT in Inflammatory and Auto-immune Disorders
T2 - Focus on Several Key Molecular Concepts, FDG, and Radiolabeled Probe Perspectives
AU - Besson, Florent L.
AU - Nocturne, Gaetane
AU - Noël, Nicolas
AU - Gheysens, Olivier
AU - Slart, Riemer H.J.A.
AU - Glaudemans, Andor W.J.M.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/5
Y1 - 2024/5
N2 - Chronic immune diseases mainly include autoimmune and inflammatory diseases. Managing chronic inflammatory and autoimmune diseases has become a significant public health concern, and therapeutic advancements over the past 50 years have been substantial. As therapeutic tools continue to multiply, the challenge now lies in providing each patient with personalized care tailored to the specifics of their condition, ushering in the era of personalized medicine. Precise and holistic imaging is essential in this context to comprehensively map the inflammatory processes in each patient, identify prognostic factors, and monitor treatment responses and complications. Imaging of patients with inflammatory and autoimmune diseases must provide a comprehensive view of the body, enabling the whole-body mapping of systemic involvement. It should identify key cellular players in the pathology, involving both innate immunity (dendritic cells, macrophages), adaptive immunity (lymphocytes), and microenvironmental cells (stromal cells, tissue cells). As a highly sensitive imaging tool with vectorized molecular probe capabilities, PET/CT can be of high relevance in the management of numerous inflammatory and autoimmune diseases. Relying on key molecular concepts of immunity, the clinical usefulness of FDG-PET/CT in several relevant inflammatory and immune-inflammatory conditions, validated or emerging, will be discussed in this review, together with radiolabeled probe perspectives.
AB - Chronic immune diseases mainly include autoimmune and inflammatory diseases. Managing chronic inflammatory and autoimmune diseases has become a significant public health concern, and therapeutic advancements over the past 50 years have been substantial. As therapeutic tools continue to multiply, the challenge now lies in providing each patient with personalized care tailored to the specifics of their condition, ushering in the era of personalized medicine. Precise and holistic imaging is essential in this context to comprehensively map the inflammatory processes in each patient, identify prognostic factors, and monitor treatment responses and complications. Imaging of patients with inflammatory and autoimmune diseases must provide a comprehensive view of the body, enabling the whole-body mapping of systemic involvement. It should identify key cellular players in the pathology, involving both innate immunity (dendritic cells, macrophages), adaptive immunity (lymphocytes), and microenvironmental cells (stromal cells, tissue cells). As a highly sensitive imaging tool with vectorized molecular probe capabilities, PET/CT can be of high relevance in the management of numerous inflammatory and autoimmune diseases. Relying on key molecular concepts of immunity, the clinical usefulness of FDG-PET/CT in several relevant inflammatory and immune-inflammatory conditions, validated or emerging, will be discussed in this review, together with radiolabeled probe perspectives.
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85178894017&partnerID=8YFLogxK
U2 - 10.1053/j.semnuclmed.2023.10.005
DO - 10.1053/j.semnuclmed.2023.10.005
M3 - Review article
C2 - 37973447
AN - SCOPUS:85178894017
SN - 0001-2998
VL - 54
SP - 379
EP - 393
JO - Seminars in Nuclear Medicine
JF - Seminars in Nuclear Medicine
IS - 3
ER -