pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces

Erik Jouwert Faber, Wouter Sparreboom, Wilrike Groeneveld, Louis C.P.M. de Smet, Johan G. Bomer, Wouter Olthuis, Han Zuilhof, Ernst Sudholter, Ernst J.R. Sudhölter, Piet Bergveld, Albert van den Berg

    Research output: Contribution to journalArticleAcademicpeer-review

    27 Citations (Scopus)

    Abstract

    The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.
    Original languageUndefined
    Article number10.1002/cphc.200600447
    Pages (from-to)101-112
    Number of pages12
    JournalChemPhysChem
    Volume8
    Issue numberWP07-01/1
    DOIs
    Publication statusPublished - 8 Jan 2007

    Keywords

    • METIS-241595
    • EWI-9710
    • IR-64001

    Cite this

    Faber, Erik Jouwert ; Sparreboom, Wouter ; Groeneveld, Wilrike ; de Smet, Louis C.P.M. ; Bomer, Johan G. ; Olthuis, Wouter ; Zuilhof, Han ; Sudholter, Ernst ; Sudhölter, Ernst J.R. ; Bergveld, Piet ; van den Berg, Albert. / pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces. In: ChemPhysChem. 2007 ; Vol. 8, No. WP07-01/1. pp. 101-112.
    @article{181629d7958a46c9b59c1933fd16bf57,
    title = "pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces",
    abstract = "The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7{\%} of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.",
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    author = "Faber, {Erik Jouwert} and Wouter Sparreboom and Wilrike Groeneveld and {de Smet}, {Louis C.P.M.} and Bomer, {Johan G.} and Wouter Olthuis and Han Zuilhof and Ernst Sudholter and Sudh{\"o}lter, {Ernst J.R.} and Piet Bergveld and {van den Berg}, Albert",
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    year = "2007",
    month = "1",
    day = "8",
    doi = "10.1002/cphc.200600447",
    language = "Undefined",
    volume = "8",
    pages = "101--112",
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    Faber, EJ, Sparreboom, W, Groeneveld, W, de Smet, LCPM, Bomer, JG, Olthuis, W, Zuilhof, H, Sudholter, E, Sudhölter, EJR, Bergveld, P & van den Berg, A 2007, 'pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces', ChemPhysChem, vol. 8, no. WP07-01/1, 10.1002/cphc.200600447, pp. 101-112. https://doi.org/10.1002/cphc.200600447

    pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces. / Faber, Erik Jouwert; Sparreboom, Wouter; Groeneveld, Wilrike; de Smet, Louis C.P.M.; Bomer, Johan G.; Olthuis, Wouter; Zuilhof, Han; Sudholter, Ernst; Sudhölter, Ernst J.R.; Bergveld, Piet; van den Berg, Albert.

    In: ChemPhysChem, Vol. 8, No. WP07-01/1, 10.1002/cphc.200600447, 08.01.2007, p. 101-112.

    Research output: Contribution to journalArticleAcademicpeer-review

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    T1 - pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces

    AU - Faber, Erik Jouwert

    AU - Sparreboom, Wouter

    AU - Groeneveld, Wilrike

    AU - de Smet, Louis C.P.M.

    AU - Bomer, Johan G.

    AU - Olthuis, Wouter

    AU - Zuilhof, Han

    AU - Sudholter, Ernst

    AU - Sudhölter, Ernst J.R.

    AU - Bergveld, Piet

    AU - van den Berg, Albert

    N1 - 10.1002/cphc.200600447

    PY - 2007/1/8

    Y1 - 2007/1/8

    N2 - The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.

    AB - The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.

    KW - METIS-241595

    KW - EWI-9710

    KW - IR-64001

    U2 - 10.1002/cphc.200600447

    DO - 10.1002/cphc.200600447

    M3 - Article

    VL - 8

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    JO - ChemPhysChem

    JF - ChemPhysChem

    SN - 1439-4235

    IS - WP07-01/1

    M1 - 10.1002/cphc.200600447

    ER -