pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces

Erik Jouwert Faber, Wouter Sparreboom, Wilrike Groeneveld, Louis C.P.M. de Smet, Johan G. Bomer, Wouter Olthuis, Han Zuilhof, Ernst Sudholter, Ernst J.R. Sudhölter, Piet Bergveld, Albert van den Berg

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.
Original languageUndefined
Article number10.1002/cphc.200600447
Pages (from-to)101-112
Number of pages12
JournalChemPhysChem
Volume8
Issue numberWP07-01/1
DOIs
Publication statusPublished - 8 Jan 2007

Keywords

  • METIS-241595
  • EWI-9710
  • IR-64001

Cite this

Faber, Erik Jouwert ; Sparreboom, Wouter ; Groeneveld, Wilrike ; de Smet, Louis C.P.M. ; Bomer, Johan G. ; Olthuis, Wouter ; Zuilhof, Han ; Sudholter, Ernst ; Sudhölter, Ernst J.R. ; Bergveld, Piet ; van den Berg, Albert. / pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces. In: ChemPhysChem. 2007 ; Vol. 8, No. WP07-01/1. pp. 101-112.
@article{181629d7958a46c9b59c1933fd16bf57,
title = "pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces",
abstract = "The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7{\%} of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.",
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author = "Faber, {Erik Jouwert} and Wouter Sparreboom and Wilrike Groeneveld and {de Smet}, {Louis C.P.M.} and Bomer, {Johan G.} and Wouter Olthuis and Han Zuilhof and Ernst Sudholter and Sudh{\"o}lter, {Ernst J.R.} and Piet Bergveld and {van den Berg}, Albert",
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day = "8",
doi = "10.1002/cphc.200600447",
language = "Undefined",
volume = "8",
pages = "101--112",
journal = "ChemPhysChem",
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Faber, EJ, Sparreboom, W, Groeneveld, W, de Smet, LCPM, Bomer, JG, Olthuis, W, Zuilhof, H, Sudholter, E, Sudhölter, EJR, Bergveld, P & van den Berg, A 2007, 'pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces' ChemPhysChem, vol. 8, no. WP07-01/1, 10.1002/cphc.200600447, pp. 101-112. https://doi.org/10.1002/cphc.200600447

pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces. / Faber, Erik Jouwert; Sparreboom, Wouter; Groeneveld, Wilrike; de Smet, Louis C.P.M.; Bomer, Johan G.; Olthuis, Wouter; Zuilhof, Han; Sudholter, Ernst; Sudhölter, Ernst J.R.; Bergveld, Piet; van den Berg, Albert.

In: ChemPhysChem, Vol. 8, No. WP07-01/1, 10.1002/cphc.200600447, 08.01.2007, p. 101-112.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces

AU - Faber, Erik Jouwert

AU - Sparreboom, Wouter

AU - Groeneveld, Wilrike

AU - de Smet, Louis C.P.M.

AU - Bomer, Johan G.

AU - Olthuis, Wouter

AU - Zuilhof, Han

AU - Sudholter, Ernst

AU - Sudhölter, Ernst J.R.

AU - Bergveld, Piet

AU - van den Berg, Albert

N1 - 10.1002/cphc.200600447

PY - 2007/1/8

Y1 - 2007/1/8

N2 - The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.

AB - The electrochemical behaviour of Si-C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiomeric biosensors, to gain fundamental knowledge on the behaviour of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO2 layers and native SiO2 layers modified with hexamethyldisilazone. All samples display pH sensitivity. The number of Si-OH groups on the alkylated samples is calculated to be less than 0.7% of that of a pure SiO2 insulator, which still causes a pH sensitivity of approximate to 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO2 (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.

KW - METIS-241595

KW - EWI-9710

KW - IR-64001

U2 - 10.1002/cphc.200600447

DO - 10.1002/cphc.200600447

M3 - Article

VL - 8

SP - 101

EP - 112

JO - ChemPhysChem

JF - ChemPhysChem

SN - 1439-4235

IS - WP07-01/1

M1 - 10.1002/cphc.200600447

ER -

Faber EJ, Sparreboom W, Groeneveld W, de Smet LCPM, Bomer JG, Olthuis W et al. pH sensitivity of Si-C linked organic monolayers on crystalline silicon surfaces. ChemPhysChem. 2007 Jan 8;8(WP07-01/1):101-112. 10.1002/cphc.200600447. https://doi.org/10.1002/cphc.200600447