Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions

Jacques A. den Boer, Ruud K.K.M. Hoenderop, Jouke Smink, J. Smink, Gerard Dornseiffen, Paul W.A.A. Koch, Cornelis H. Slump, Jan H. Mulder, Edo D.P. Volker, J.H. Mulder, Rob A.I. de Vos

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Abstract

The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.
Original languageUndefined
Pages (from-to)702-715
Number of pages14
JournalJournal of magnetic resonance imaging
Volume7
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • METIS-112344
  • Gd-DTPA
  • Magnetic resonance imaging
  • IR-71339
  • Pharmacokinetics Breast lesions

Cite this

den Boer, J. A., Hoenderop, R. K. K. M., Smink, J., Smink, J., Dornseiffen, G., Koch, P. W. A. A., ... de Vos, R. A. I. (1997). Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. Journal of magnetic resonance imaging, 7(4), 702-715. https://doi.org/10.1002/jmri.1880070416
den Boer, Jacques A. ; Hoenderop, Ruud K.K.M. ; Smink, Jouke ; Smink, J. ; Dornseiffen, Gerard ; Koch, Paul W.A.A. ; Slump, Cornelis H. ; Mulder, Jan H. ; Volker, Edo D.P. ; Mulder, J.H. ; de Vos, Rob A.I. / Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. In: Journal of magnetic resonance imaging. 1997 ; Vol. 7, No. 4. pp. 702-715.
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title = "Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions",
abstract = "The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92{\%} and a specificity of 70{\%}. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.",
keywords = "METIS-112344, Gd-DTPA, Magnetic resonance imaging, IR-71339, Pharmacokinetics Breast lesions",
author = "{den Boer}, {Jacques A.} and Hoenderop, {Ruud K.K.M.} and Jouke Smink and J. Smink and Gerard Dornseiffen and Koch, {Paul W.A.A.} and Slump, {Cornelis H.} and Mulder, {Jan H.} and Volker, {Edo D.P.} and J.H. Mulder and {de Vos}, {Rob A.I.}",
year = "1997",
doi = "10.1002/jmri.1880070416",
language = "Undefined",
volume = "7",
pages = "702--715",
journal = "Journal of magnetic resonance imaging",
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den Boer, JA, Hoenderop, RKKM, Smink, J, Smink, J, Dornseiffen, G, Koch, PWAA, Slump, CH, Mulder, JH, Volker, EDP, Mulder, JH & de Vos, RAI 1997, 'Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions' Journal of magnetic resonance imaging, vol. 7, no. 4, pp. 702-715. https://doi.org/10.1002/jmri.1880070416

Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. / den Boer, Jacques A.; Hoenderop, Ruud K.K.M.; Smink, Jouke; Smink, J.; Dornseiffen, Gerard; Koch, Paul W.A.A.; Slump, Cornelis H.; Mulder, Jan H.; Volker, Edo D.P.; Mulder, J.H.; de Vos, Rob A.I.

In: Journal of magnetic resonance imaging, Vol. 7, No. 4, 1997, p. 702-715.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions

AU - den Boer, Jacques A.

AU - Hoenderop, Ruud K.K.M.

AU - Smink, Jouke

AU - Smink, J.

AU - Dornseiffen, Gerard

AU - Koch, Paul W.A.A.

AU - Slump, Cornelis H.

AU - Mulder, Jan H.

AU - Volker, Edo D.P.

AU - Mulder, J.H.

AU - de Vos, Rob A.I.

PY - 1997

Y1 - 1997

N2 - The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.

AB - The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.

KW - METIS-112344

KW - Gd-DTPA

KW - Magnetic resonance imaging

KW - IR-71339

KW - Pharmacokinetics Breast lesions

U2 - 10.1002/jmri.1880070416

DO - 10.1002/jmri.1880070416

M3 - Article

VL - 7

SP - 702

EP - 715

JO - Journal of magnetic resonance imaging

JF - Journal of magnetic resonance imaging

SN - 1053-1807

IS - 4

ER -