Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions

Jacques A. den Boer, Ruud K.K.M. Hoenderop, Jouke Smink, J. Smink, Gerard Dornseiffen, Paul W.A.A. Koch, Cornelis H. Slump, Jan H. Mulder, Edo D.P. Volker, J.H. Mulder, Rob A.I. de Vos

    Research output: Contribution to journalArticleAcademicpeer-review

    55 Citations (Scopus)
    72 Downloads (Pure)

    Abstract

    The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.
    Original languageUndefined
    Pages (from-to)702-715
    Number of pages14
    JournalJournal of magnetic resonance imaging
    Volume7
    Issue number4
    DOIs
    Publication statusPublished - 1997

    Keywords

    • METIS-112344
    • Gd-DTPA
    • Magnetic resonance imaging
    • IR-71339
    • Pharmacokinetics Breast lesions

    Cite this

    den Boer, J. A., Hoenderop, R. K. K. M., Smink, J., Smink, J., Dornseiffen, G., Koch, P. W. A. A., ... de Vos, R. A. I. (1997). Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. Journal of magnetic resonance imaging, 7(4), 702-715. https://doi.org/10.1002/jmri.1880070416
    den Boer, Jacques A. ; Hoenderop, Ruud K.K.M. ; Smink, Jouke ; Smink, J. ; Dornseiffen, Gerard ; Koch, Paul W.A.A. ; Slump, Cornelis H. ; Mulder, Jan H. ; Volker, Edo D.P. ; Mulder, J.H. ; de Vos, Rob A.I. / Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. In: Journal of magnetic resonance imaging. 1997 ; Vol. 7, No. 4. pp. 702-715.
    @article{b1498cdd8fbd4a1795b64aa9a24513f5,
    title = "Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions",
    abstract = "The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92{\%} and a specificity of 70{\%}. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.",
    keywords = "METIS-112344, Gd-DTPA, Magnetic resonance imaging, IR-71339, Pharmacokinetics Breast lesions",
    author = "{den Boer}, {Jacques A.} and Hoenderop, {Ruud K.K.M.} and Jouke Smink and J. Smink and Gerard Dornseiffen and Koch, {Paul W.A.A.} and Slump, {Cornelis H.} and Mulder, {Jan H.} and Volker, {Edo D.P.} and J.H. Mulder and {de Vos}, {Rob A.I.}",
    year = "1997",
    doi = "10.1002/jmri.1880070416",
    language = "Undefined",
    volume = "7",
    pages = "702--715",
    journal = "Journal of magnetic resonance imaging",
    issn = "1053-1807",
    publisher = "Wiley",
    number = "4",

    }

    den Boer, JA, Hoenderop, RKKM, Smink, J, Smink, J, Dornseiffen, G, Koch, PWAA, Slump, CH, Mulder, JH, Volker, EDP, Mulder, JH & de Vos, RAI 1997, 'Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions', Journal of magnetic resonance imaging, vol. 7, no. 4, pp. 702-715. https://doi.org/10.1002/jmri.1880070416

    Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions. / den Boer, Jacques A.; Hoenderop, Ruud K.K.M.; Smink, Jouke; Smink, J.; Dornseiffen, Gerard; Koch, Paul W.A.A.; Slump, Cornelis H.; Mulder, Jan H.; Volker, Edo D.P.; Mulder, J.H.; de Vos, Rob A.I.

    In: Journal of magnetic resonance imaging, Vol. 7, No. 4, 1997, p. 702-715.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Pharmacokinetic Analysis of Gd-DTPA Enhancement in Dynamic Three-Dimensional MRI of Breast Lesions

    AU - den Boer, Jacques A.

    AU - Hoenderop, Ruud K.K.M.

    AU - Smink, Jouke

    AU - Smink, J.

    AU - Dornseiffen, Gerard

    AU - Koch, Paul W.A.A.

    AU - Slump, Cornelis H.

    AU - Mulder, Jan H.

    AU - Volker, Edo D.P.

    AU - Mulder, J.H.

    AU - de Vos, Rob A.I.

    PY - 1997

    Y1 - 1997

    N2 - The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.

    AB - The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant.

    KW - METIS-112344

    KW - Gd-DTPA

    KW - Magnetic resonance imaging

    KW - IR-71339

    KW - Pharmacokinetics Breast lesions

    U2 - 10.1002/jmri.1880070416

    DO - 10.1002/jmri.1880070416

    M3 - Article

    VL - 7

    SP - 702

    EP - 715

    JO - Journal of magnetic resonance imaging

    JF - Journal of magnetic resonance imaging

    SN - 1053-1807

    IS - 4

    ER -