Abstract
In this work we show phase 1 and 2 drug metabolism using a miniaturized electrochemical cell followed by on-line metabolite detection using electrospray ionization – mass spectrometry (ESI-MS). The most common form of in vivo drug metabolism is enzyme-catalyzed oxidation [1]. Therefore, a method to rapidly mimic these reactions and subsequently analyze the products is interesting for drug screening applications. With the versatile experimental setup presented, phase 1 metabolism of clozapine is carried out with a very short transfer time to detection, as well as phase 1 and 2 metabolism of paracetamol which is first oxidized and subsequently conjugated to glutathione
Original language | Undefined |
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Title of host publication | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS |
Editors | R. Zengerle |
Place of Publication | Freiburg |
Publisher | The Printing House |
Pages | 11-13 |
Number of pages | 3 |
ISBN (Print) | 978-0-9798064-6-9 |
Publication status | Published - 27 Oct 2013 |
Event | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2013 - Freiburg, Germany Duration: 27 Oct 2013 → 31 Oct 2013 Conference number: 17 |
Publication series
Name | MicroTAS |
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Publisher | The Printing House |
Number | MicroTAS 2013 |
ISSN (Print) | 1556-5904 |
Conference
Conference | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2013 |
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Abbreviated title | MicroTAS |
Country/Territory | Germany |
City | Freiburg |
Period | 27/10/13 → 31/10/13 |
Keywords
- EWI-24045
- METIS-300191
- IR-88072