TY - JOUR
T1 - Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony
T2 - A narrative overview
AU - Juarez-Orozco, Luis Eduardo
AU - Monroy-Gonzalez, Andrea
AU - Prakken, Niek H.J.
AU - Noordzij, Walter
AU - Knuuti, Juhani
AU - deKemp, Robert A.
AU - Slart, Riemer H.J.A.
N1 - Springer deal
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Noninvasive imaging modalities offer the possibility to dynamically evaluate cardiac motion during the cardiac cycle by means of ECG-gated acquisitions. Such motion characterization along with orientation, segmentation preprocessing, and ultimately, phase analysis, can provide quantitative estimates of ventricular mechanical synchrony. Current evidence on the role of mechanical synchrony evaluation is mainly available for echocardiography and gated single-photon emission computed tomography, but less is known about the utilization of gated positron emission tomography (PET). Although data available are sparse, there is indication that mechanical synchrony evaluation can be of diagnostic and prognostic values in patients with known or suspected coronary artery disease-related myocardial ischemia, prediction of response to cardiac resynchronization therapy, and estimation of risk for adverse cardiac events in patients’ heart failure. As such, the evaluation of mechanical ventricular synchrony through phase analysis of gated acquisitions represents a value addition to modern cardiac PET imaging modality, which warrants further research and development in the evaluation of patients with cardiovascular disease.
AB - Noninvasive imaging modalities offer the possibility to dynamically evaluate cardiac motion during the cardiac cycle by means of ECG-gated acquisitions. Such motion characterization along with orientation, segmentation preprocessing, and ultimately, phase analysis, can provide quantitative estimates of ventricular mechanical synchrony. Current evidence on the role of mechanical synchrony evaluation is mainly available for echocardiography and gated single-photon emission computed tomography, but less is known about the utilization of gated positron emission tomography (PET). Although data available are sparse, there is indication that mechanical synchrony evaluation can be of diagnostic and prognostic values in patients with known or suspected coronary artery disease-related myocardial ischemia, prediction of response to cardiac resynchronization therapy, and estimation of risk for adverse cardiac events in patients’ heart failure. As such, the evaluation of mechanical ventricular synchrony through phase analysis of gated acquisitions represents a value addition to modern cardiac PET imaging modality, which warrants further research and development in the evaluation of patients with cardiovascular disease.
KW - UT-Hybrid-D
KW - phase analysis
KW - Ventricular synchrony
KW - gated PET
UR - http://www.scopus.com/inward/record.url?scp=85062692198&partnerID=8YFLogxK
U2 - 10.1007/s12350-019-01670-7
DO - 10.1007/s12350-019-01670-7
M3 - Review article
C2 - 30834496
AN - SCOPUS:85062692198
SN - 1071-3581
VL - 26
SP - 1904
EP - 1913
JO - Journal of nuclear cardiology
JF - Journal of nuclear cardiology
IS - 6
ER -