Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus

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Abstract

The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.
Original languageEnglish
Article number111
Number of pages10
JournalFrontiers in systems neuroscience
Volume7
DOIs
Publication statusPublished - 16 Dec 2013

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Status Epilepticus
Neurons
Electroencephalography

Keywords

  • EWI-24069
  • spike-wave discharge
  • phase-locking
  • Absence status
  • thalamo-cortical system
  • absence seizure
  • IR-88276
  • delta oscillation
  • METIS-301590

Cite this

@article{318da21c91b546c6835f0e4a332d8286,
title = "Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus",
abstract = "The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.",
keywords = "EWI-24069, spike-wave discharge, phase-locking, Absence status, thalamo-cortical system, absence seizure, IR-88276, delta oscillation, METIS-301590",
author = "Rikkert Hindriks and Meijer, {Hil Ga{\'e}tan Ellart} and {van Gils}, {Stephanus A.} and {van Putten}, {Michel Johannes Antonius Maria}",
year = "2013",
month = "12",
day = "16",
doi = "10.3389/fnsys.2013.00111",
language = "English",
volume = "7",
journal = "Frontiers in systems neuroscience",
issn = "1662-5137",
publisher = "Frontiers Media S.A.",

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TY - JOUR

T1 - Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus

AU - Hindriks, Rikkert

AU - Meijer, Hil Gaétan Ellart

AU - van Gils, Stephanus A.

AU - van Putten, Michel Johannes Antonius Maria

PY - 2013/12/16

Y1 - 2013/12/16

N2 - The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.

AB - The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.

KW - EWI-24069

KW - spike-wave discharge

KW - phase-locking

KW - Absence status

KW - thalamo-cortical system

KW - absence seizure

KW - IR-88276

KW - delta oscillation

KW - METIS-301590

U2 - 10.3389/fnsys.2013.00111

DO - 10.3389/fnsys.2013.00111

M3 - Article

VL - 7

JO - Frontiers in systems neuroscience

JF - Frontiers in systems neuroscience

SN - 1662-5137

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ER -