Photo-Crosslinked Biodegradable Hydrogels Prepared From Fumaric Acid Monoethyl Ester-Functionalized Oligomers for Protein Delivery

J. Jansen, G. Mihov, Jan Feijen, Dirk W. Grijpma

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.
Original languageEnglish
Pages (from-to)692-702
JournalMacromolecular bioscience
Volume12
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • METIS-288333
  • IR-81697

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