Photo-crosslinked synthetic biodegradable polymer networks for biomedical applications

Bas van Bochove, Dirk W. Grijpma (Corresponding Author)

Research output: Contribution to journalReview articleAcademicpeer-review

6 Citations (Scopus)

Abstract

Photo-crosslinked synthetic biodegradable polymer networks are highly interesting materials for utilization in biomedical applications such as drug delivery, cell encapsulation and tissue engineering scaffolds. Varying the architecture, chemistry, degree of functionalization and molecular weight of the macromer precursor molecules results in networks with a wide range of physical- and mechanical properties, crosslinking densities, degradation characteristics and thus in potential applications. Photo-crosslinked networks can easily be prepared and have the possibility to entrap a wide range of (biologically active) substances and cells. Additionally, spatial and temporal control over the crosslinking process when using additive manufacturing processes, allows for the preparation of network structures with complex shapes. Photo-crosslinked networks have been used to prepare drug delivery devices, as these networks allow for drug delivery in a controlled way over a prolonged period of time. Furthermore, additive manufacturing techniques such as extrusion-based additive manufacturing and stereolithography have been used to prepare photo-crosslinked tissue engineering scaffolds. This allows for the preparation of designed porous structures with precise control over the pore size and pore architecture and optimal mechanical properties. In particular for stereolithography, a wide variety of resins based on biodegradable photo-crosslinkable macromers has been developed.

Original languageEnglish
Pages (from-to)77-106
Number of pages30
JournalJournal of Biomaterials Science, Polymer Edition
Volume30
Issue number2
DOIs
Publication statusPublished - 22 Jan 2019

Fingerprint

3D printers
Biodegradable polymers
Drug delivery
Tissue Scaffolds
Stereolithography
Polymers
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Crosslinking
Pharmaceutical Preparations
Cell Engineering
Mechanical properties
Encapsulation
Pore size
Extrusion
Resins
Physical properties
Molecular Weight
Molecular weight

Keywords

  • biodegradable polymer networks
  • biomedical applications
  • Photo-crosslinking
  • stereolithography

Cite this

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Photo-crosslinked synthetic biodegradable polymer networks for biomedical applications. / van Bochove, Bas; Grijpma, Dirk W. (Corresponding Author).

In: Journal of Biomaterials Science, Polymer Edition, Vol. 30, No. 2, 22.01.2019, p. 77-106.

Research output: Contribution to journalReview articleAcademicpeer-review

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