Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds

F.P.W. Melchels; Dirk W. Grijpma; Jan Feijen

doi:10.1016/j.jconrel.2006.09.070

Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds

F.P.W. Melchels, Dirk W. Grijpma, Jan Feijen

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Abstract

In the fabrication of osteochondral tissue engineering scaffolds, the two distinct tissues impose different requirements on the architecture. Stereo-lithography is a rapid prototyping method that can be utilised to make 3D constructs with high spatial control by radical photo-polymerisation. In this study, biodegradable resins are developed that can be applied in stereo-lithography. Photo-crosslinked poly(lactide) networks with varying physical properties were synthesised, and by photo-polymerising in the presence of leachable particles porous scaffolds could be prepared as well.

Original language	Undefined
Pages (from-to)	e98-e100
Journal	Journal of controlled release
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.070
Publication status	Published - 2006

Keywords

METIS-245520
IR-71114
EC Grant Agreement nr.: FP6/500465

Access to Document

10.1016/j.jconrel.2006.09.070

Cite this

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title = "Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds",

abstract = "In the fabrication of osteochondral tissue engineering scaffolds, the two distinct tissues impose different requirements on the architecture. Stereo-lithography is a rapid prototyping method that can be utilised to make 3D constructs with high spatial control by radical photo-polymerisation. In this study, biodegradable resins are developed that can be applied in stereo-lithography. Photo-crosslinked poly(lactide) networks with varying physical properties were synthesised, and by photo-polymerising in the presence of leachable particles porous scaffolds could be prepared as well.",

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author = "F.P.W. Melchels and Grijpma, {Dirk W.} and Jan Feijen",

note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ",

year = "2006",

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T1 - Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds

AU - Melchels, F.P.W.

AU - Grijpma, Dirk W.

AU - Feijen, Jan

N1 - Proceedings of the Ninth European Symposium on Controlled Drug Delivery

PY - 2006

Y1 - 2006

N2 - In the fabrication of osteochondral tissue engineering scaffolds, the two distinct tissues impose different requirements on the architecture. Stereo-lithography is a rapid prototyping method that can be utilised to make 3D constructs with high spatial control by radical photo-polymerisation. In this study, biodegradable resins are developed that can be applied in stereo-lithography. Photo-crosslinked poly(lactide) networks with varying physical properties were synthesised, and by photo-polymerising in the presence of leachable particles porous scaffolds could be prepared as well.

AB - In the fabrication of osteochondral tissue engineering scaffolds, the two distinct tissues impose different requirements on the architecture. Stereo-lithography is a rapid prototyping method that can be utilised to make 3D constructs with high spatial control by radical photo-polymerisation. In this study, biodegradable resins are developed that can be applied in stereo-lithography. Photo-crosslinked poly(lactide) networks with varying physical properties were synthesised, and by photo-polymerising in the presence of leachable particles porous scaffolds could be prepared as well.

KW - METIS-245520

KW - IR-71114

KW - EC Grant Agreement nr.: FP6/500465

U2 - 10.1016/j.jconrel.2006.09.070

DO - 10.1016/j.jconrel.2006.09.070

M3 - Article

SN - 0168-3659

VL - 116

SP - e98-e100

JO - Journal of controlled release

JF - Journal of controlled release

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