Photoacoustic 3D visualization of tumor angiogenesis

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Photoacoustic imaging is used to obtain a range of three-dimensional images representing tumor neovascularization over a 10-day period after subcutaneous inoculation of pancreatic tumor cells in a rat. The images are reconstructed from data measured with a double-ring photoacoustic detector. The ultrasound data originates from the optical absorption by hemoglobin of 14 ns laser pulses at a wavelength of 1064 nm. Three-dimensional data is obtained by using two dimensional linear scanning. Scanning and motion artifacts are reduced using a correction method. The data is used to visualize the development of the individual blood vessels around the growing tumor, blood concentration changes inside the tumor and growth in depth of the neovascularized region. The three-dimensional vasculature reconstruction is created using VTK, which enables us to create a composition of the vasculature on day seven, eight and ten and to interactively measure tumor growth in the near future.
Original languageEnglish
Title of host publicationMedical Imaging 2008
Subtitle of host publicationUltrasonic Imaging and Signal Processing: 17–18 February 2008, San Diego, California, USA
EditorsStephen A. McAleavey, Jan D'hooge
Place of PublicationSan Diego
Number of pages7
ISBN (Print)9780819471048
Publication statusPublished - 13 Mar 2008
EventSPIE Medical Imaging 2008 - Town & Country Resort and Convention Center, San Diego, United States
Duration: 16 Feb 200821 Feb 2008

Publication series

NameProceedings of SPIE
ISSN (Print)1605-7422


ConferenceSPIE Medical Imaging 2008
Country/TerritoryUnited States
CitySan Diego


  • METIS-247897
  • IR-62319
  • EWI-12795


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