Photoacoustic assisted device guidance and thermal lesion imaging for radiofrequency ablation

K. J. Francis, Srirang Manohar

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
125 Downloads (Pure)


Radiofrequency ablation (RFA) is a widely used treatment method for unresectable malignant tumors. In percutaneous RFA, the tumor recurrence rate is high due to incomplete ablation. Feedback from the imaging system during the RFA procedure is vital in reducing the tumor recurrence. We propose the use of photoacoustic (PA) imaging, integrated with an ultrasound (US) system to monitor the RFA procedure. The imaging system consists of a US system with a linear array and a pulsed laser illumination. We study the PA assisted RFA device guidance to an anomalous target embedded inside a chicken breast tissue. We compare both US and PA images to highlight the advantage of using the proposed method. Further, we image an ablated ex vivo bovine liver sample using the system. The result shows a drop in PA intensity from the ablated region compared to normal tissue. Our preliminary study shows that PA imaging is a potential modality for RFA procedures.
Original languageEnglish
Title of host publicationProceedings Opto-Acoustic Methods and Applications in Biophotonics IV
EditorsVasilis Ntziachristos, Roger Zemp
Number of pages3
ISBN (Electronic)9781510628472
ISBN (Print)978-1-5106-2847-2
Publication statusPublished - 20 Jul 2019
EventEuropean Conferences on Biomedical Optics 2019 - ICM─International Congress Center, Munich, Germany
Duration: 23 Jun 201927 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEuropean Conferences on Biomedical Optics 2019


  • Bovine liver
  • Ex vivo
  • Photoacoustic Imaging
  • Radiofrequency ablation
  • Real-time guidance
  • Ultrasound
  • ex vivo


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