Photoacoustic determination of blood vessel diameter

R.G.M. Kolkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen C.W. Hopman, F.F.M. de Mul, Wiendelt Steenbergen, Johan M. Thijssen, Ton van Leeuwen

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Abstract

A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-topeak time (τ pp) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2cτ pp, with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution.
Original languageUndefined
Pages (from-to)4745-4756
Number of pages12
JournalPhysics in medicine and biology
Volume49
Issue number20
DOIs
Publication statusPublished - 2004

Keywords

  • IR-47861
  • METIS-218823

Cite this

Kolkman, R. G. M., Klaessens, J. H. G. M., Hondebrink, E., Hopman, J. C. W., de Mul, F. F. M., Steenbergen, W., ... van Leeuwen, T. (2004). Photoacoustic determination of blood vessel diameter. Physics in medicine and biology, 49(20), 4745-4756. https://doi.org/10.1088/0031-9155/49/20/006
Kolkman, R.G.M. ; Klaessens, John H.G.M. ; Hondebrink, Erwin ; Hopman, Jeroen C.W. ; de Mul, F.F.M. ; Steenbergen, Wiendelt ; Thijssen, Johan M. ; van Leeuwen, Ton. / Photoacoustic determination of blood vessel diameter. In: Physics in medicine and biology. 2004 ; Vol. 49, No. 20. pp. 4745-4756.
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title = "Photoacoustic determination of blood vessel diameter",
abstract = "A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-topeak time (τ pp) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2cτ pp, with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution.",
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Kolkman, RGM, Klaessens, JHGM, Hondebrink, E, Hopman, JCW, de Mul, FFM, Steenbergen, W, Thijssen, JM & van Leeuwen, T 2004, 'Photoacoustic determination of blood vessel diameter', Physics in medicine and biology, vol. 49, no. 20, pp. 4745-4756. https://doi.org/10.1088/0031-9155/49/20/006

Photoacoustic determination of blood vessel diameter. / Kolkman, R.G.M.; Klaessens, John H.G.M.; Hondebrink, Erwin; Hopman, Jeroen C.W.; de Mul, F.F.M.; Steenbergen, Wiendelt; Thijssen, Johan M.; van Leeuwen, Ton.

In: Physics in medicine and biology, Vol. 49, No. 20, 2004, p. 4745-4756.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Photoacoustic determination of blood vessel diameter

AU - Kolkman, R.G.M.

AU - Klaessens, John H.G.M.

AU - Hondebrink, Erwin

AU - Hopman, Jeroen C.W.

AU - de Mul, F.F.M.

AU - Steenbergen, Wiendelt

AU - Thijssen, Johan M.

AU - van Leeuwen, Ton

PY - 2004

Y1 - 2004

N2 - A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-topeak time (τ pp) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2cτ pp, with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution.

AB - A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-topeak time (τ pp) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2cτ pp, with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution.

KW - IR-47861

KW - METIS-218823

U2 - 10.1088/0031-9155/49/20/006

DO - 10.1088/0031-9155/49/20/006

M3 - Article

VL - 49

SP - 4745

EP - 4756

JO - Physics in medicine and biology

JF - Physics in medicine and biology

SN - 0031-9155

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Kolkman RGM, Klaessens JHGM, Hondebrink E, Hopman JCW, de Mul FFM, Steenbergen W et al. Photoacoustic determination of blood vessel diameter. Physics in medicine and biology. 2004;49(20):4745-4756. https://doi.org/10.1088/0031-9155/49/20/006