Photoacoustic-guided focused ultrasound for accurate visualization of brachytherapy seeds with the photoacoustic needle

M. Kuniyil Ajith Singh, Vinay Parameshwarappa, E. Hendriksen, Wiendelt Steenbergen, Srirang Manohar

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

An important problem in minimally invasive photoacoustic (PA) imaging of brachytherapy seeds is reflection artifacts caused by the high signal from the optical fiber/needle tip reflecting off the seed. The presence of these artifacts confounds interpretation of images. In this letter, we demonstrate a recently developed concept called photoacoustic-guided focused ultrasound (PAFUSion) for the first time in the context of interstitial illumination PA imaging to identify and remove reflection artifacts. In this method, ultrasound (US) from the transducer is focused on the region of the optical fiber/needle tip identified in a first step using PA imaging. The image developed from the US diverging from the focus zone at the tip region visualizes only the reflections from seeds and other acoustic inhomogeneities, allowing identification of the reflection artifacts of the first step. These artifacts can then be removed from the PA image. Using PAFUSion, we demonstrate reduction of reflection artifacts and thereby improved interstitial PA visualization of brachytherapy seeds in phantom and ex vivo measurements on porcine tissue.
Original languageUndefined
Article number120501
Pages (from-to)-
Number of pages5
JournalJournal of biomedical optics
Volume21
Issue number12
DOIs
Publication statusPublished - 2016

Keywords

  • IR-103713
  • METIS-318982

Cite this

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title = "Photoacoustic-guided focused ultrasound for accurate visualization of brachytherapy seeds with the photoacoustic needle",
abstract = "An important problem in minimally invasive photoacoustic (PA) imaging of brachytherapy seeds is reflection artifacts caused by the high signal from the optical fiber/needle tip reflecting off the seed. The presence of these artifacts confounds interpretation of images. In this letter, we demonstrate a recently developed concept called photoacoustic-guided focused ultrasound (PAFUSion) for the first time in the context of interstitial illumination PA imaging to identify and remove reflection artifacts. In this method, ultrasound (US) from the transducer is focused on the region of the optical fiber/needle tip identified in a first step using PA imaging. The image developed from the US diverging from the focus zone at the tip region visualizes only the reflections from seeds and other acoustic inhomogeneities, allowing identification of the reflection artifacts of the first step. These artifacts can then be removed from the PA image. Using PAFUSion, we demonstrate reduction of reflection artifacts and thereby improved interstitial PA visualization of brachytherapy seeds in phantom and ex vivo measurements on porcine tissue.",
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note = "Open access",
year = "2016",
doi = "10.1117/1.JBO.21.12.120501",
language = "Undefined",
volume = "21",
pages = "--",
journal = "Journal of biomedical optics",
issn = "1083-3668",
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Photoacoustic-guided focused ultrasound for accurate visualization of brachytherapy seeds with the photoacoustic needle. / Kuniyil Ajith Singh, M.; Parameshwarappa, Vinay; Hendriksen, E.; Steenbergen, Wiendelt; Manohar, Srirang.

In: Journal of biomedical optics, Vol. 21, No. 12, 120501, 2016, p. -.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Photoacoustic-guided focused ultrasound for accurate visualization of brachytherapy seeds with the photoacoustic needle

AU - Kuniyil Ajith Singh, M.

AU - Parameshwarappa, Vinay

AU - Hendriksen, E.

AU - Steenbergen, Wiendelt

AU - Manohar, Srirang

N1 - Open access

PY - 2016

Y1 - 2016

N2 - An important problem in minimally invasive photoacoustic (PA) imaging of brachytherapy seeds is reflection artifacts caused by the high signal from the optical fiber/needle tip reflecting off the seed. The presence of these artifacts confounds interpretation of images. In this letter, we demonstrate a recently developed concept called photoacoustic-guided focused ultrasound (PAFUSion) for the first time in the context of interstitial illumination PA imaging to identify and remove reflection artifacts. In this method, ultrasound (US) from the transducer is focused on the region of the optical fiber/needle tip identified in a first step using PA imaging. The image developed from the US diverging from the focus zone at the tip region visualizes only the reflections from seeds and other acoustic inhomogeneities, allowing identification of the reflection artifacts of the first step. These artifacts can then be removed from the PA image. Using PAFUSion, we demonstrate reduction of reflection artifacts and thereby improved interstitial PA visualization of brachytherapy seeds in phantom and ex vivo measurements on porcine tissue.

AB - An important problem in minimally invasive photoacoustic (PA) imaging of brachytherapy seeds is reflection artifacts caused by the high signal from the optical fiber/needle tip reflecting off the seed. The presence of these artifacts confounds interpretation of images. In this letter, we demonstrate a recently developed concept called photoacoustic-guided focused ultrasound (PAFUSion) for the first time in the context of interstitial illumination PA imaging to identify and remove reflection artifacts. In this method, ultrasound (US) from the transducer is focused on the region of the optical fiber/needle tip identified in a first step using PA imaging. The image developed from the US diverging from the focus zone at the tip region visualizes only the reflections from seeds and other acoustic inhomogeneities, allowing identification of the reflection artifacts of the first step. These artifacts can then be removed from the PA image. Using PAFUSion, we demonstrate reduction of reflection artifacts and thereby improved interstitial PA visualization of brachytherapy seeds in phantom and ex vivo measurements on porcine tissue.

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