Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology

M. Heijblom, D. Piras, M. Brinkhuis, Johannes C.G. van Hespen, F.M. van den Engh, M. van der Schaaf, J.M. Klaase, Ton van Leeuwen, Wiendelt Steenbergen, Srirang Manohar

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Abstract

Photoacoustic (optoacoustic) imaging can visualize vasculature deep in tissue using the high contrast of hemoglobin to light, with the high-resolution possible with ultrasound detection. Since angiogenesis, one of the hallmarks of cancer, leads to increased vascularity, photoacoustics holds promise in imaging breast cancer as shown in proof-of-principle studies. Here for the first time, we investigate if there are specific photoacoustic appearances of breast malignancies which can be related to the tumor vascularity, using an upgraded research imaging system, the Twente Photoacoustic Mammoscope. In addition to comparisons with x-ray and ultrasound images, in subsets of cases the photoacoustic images were compared with MR images, and with vascular staining in histopathology. We were able to identify lesions in suspect breasts at the expected locations in 28 of 29 cases. We discovered generally three types of photoacoustic appearances reminiscent of contrast enhancement types reported in MR imaging of breast malignancies, and first insights were gained into the relationship with tumor vascularity
Original languageEnglish
Article number11778
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015

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breast
magnetic resonance
cancer
tumors
angiogenesis
hemoglobin
staining
lesions
set theory
augmentation
high resolution
x rays

Keywords

  • IR-99265
  • METIS-312200

Cite this

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title = "Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology",
abstract = "Photoacoustic (optoacoustic) imaging can visualize vasculature deep in tissue using the high contrast of hemoglobin to light, with the high-resolution possible with ultrasound detection. Since angiogenesis, one of the hallmarks of cancer, leads to increased vascularity, photoacoustics holds promise in imaging breast cancer as shown in proof-of-principle studies. Here for the first time, we investigate if there are specific photoacoustic appearances of breast malignancies which can be related to the tumor vascularity, using an upgraded research imaging system, the Twente Photoacoustic Mammoscope. In addition to comparisons with x-ray and ultrasound images, in subsets of cases the photoacoustic images were compared with MR images, and with vascular staining in histopathology. We were able to identify lesions in suspect breasts at the expected locations in 28 of 29 cases. We discovered generally three types of photoacoustic appearances reminiscent of contrast enhancement types reported in MR imaging of breast malignancies, and first insights were gained into the relationship with tumor vascularity",
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note = "Open access",
year = "2015",
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language = "English",
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journal = "Scientific reports",
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Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology. / Heijblom, M.; Piras, D.; Brinkhuis, M.; van Hespen, Johannes C.G.; van den Engh, F.M.; van der Schaaf, M.; Klaase, J.M.; van Leeuwen, Ton; Steenbergen, Wiendelt; Manohar, Srirang.

In: Scientific reports, Vol. 5, 11778, 2015.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Heijblom, M.

AU - Piras, D.

AU - Brinkhuis, M.

AU - van Hespen, Johannes C.G.

AU - van den Engh, F.M.

AU - van der Schaaf, M.

AU - Klaase, J.M.

AU - van Leeuwen, Ton

AU - Steenbergen, Wiendelt

AU - Manohar, Srirang

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