TY - GEN
T1 - Photoacoustic Imaging of Colorectal Cancer in Ex-vivo Samples
T2 - Photons Plus Ultrasound: Imaging and Sensing 2024
AU - Ghanbarzadeh-Dagheyan, Ashkan
AU - Francis, Kalloor Joseph
AU - Mooij, Cyrille
AU - van der Stel, Stefan
AU - Kuniyil Ajith Singh, Mithun
AU - Ruers, Theo
N1 - Publisher Copyright:
© 2024 SPIE.
PY - 2024
Y1 - 2024
N2 - Colorectal cancer claimed nearly 1 million lives in 2022. According to World Health Organization, the prevalence and mortality rates of this disease are on the rise in the world, mainly due to an unhealthy diet, low in fiber. Recently, neoadjuvant therapy, which is a combination of chemo- and radiotherapy, has gained more attention over radical surgery for responsive patients. This is because if the patient responds excellently to neoadjuvant therapy, through monitoring, radical surgery could be avoided, saving the patient's organ and bettering their quality of life. However, presently, monitoring is limited using MRI and colonoscopy, making decisions about the patient's status difficult after therapy. New modalities such as photoacoustic (PA) imaging may help improve the monitoring by distinguishing between malignant and healthy or fibrotic tissue. In this work, we carry out a preliminary study on the use of LED-based PA imaging on colorectal samples ex vivo, in a preclinical setting. Our analysis shows that the PA image intensity is lower in the malignant tissue than the fatty tissue. However, our results are inconclusive about the difference between tumor and healthy colorectal tissue due to limited data and the effect of depth on the PA signal. For future research, collecting more data and the use of a tunable laser source are recommended.
AB - Colorectal cancer claimed nearly 1 million lives in 2022. According to World Health Organization, the prevalence and mortality rates of this disease are on the rise in the world, mainly due to an unhealthy diet, low in fiber. Recently, neoadjuvant therapy, which is a combination of chemo- and radiotherapy, has gained more attention over radical surgery for responsive patients. This is because if the patient responds excellently to neoadjuvant therapy, through monitoring, radical surgery could be avoided, saving the patient's organ and bettering their quality of life. However, presently, monitoring is limited using MRI and colonoscopy, making decisions about the patient's status difficult after therapy. New modalities such as photoacoustic (PA) imaging may help improve the monitoring by distinguishing between malignant and healthy or fibrotic tissue. In this work, we carry out a preliminary study on the use of LED-based PA imaging on colorectal samples ex vivo, in a preclinical setting. Our analysis shows that the PA image intensity is lower in the malignant tissue than the fatty tissue. However, our results are inconclusive about the difference between tumor and healthy colorectal tissue due to limited data and the effect of depth on the PA signal. For future research, collecting more data and the use of a tunable laser source are recommended.
KW - 2024 OA procedure
KW - Colorectal cancer
KW - Photoacoustic imaging
KW - Ultrasound imaging
KW - Cancer detection
UR - http://www.scopus.com/inward/record.url?scp=85194504230&partnerID=8YFLogxK
U2 - 10.1117/12.3002767
DO - 10.1117/12.3002767
M3 - Conference contribution
AN - SCOPUS:85194504230
T3 - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
Y2 - 28 January 2024 through 31 January 2024
ER -