Photoacoustic Imaging of Colorectal Cancer in Ex-vivo Samples: A Preliminary Study

Ashkan Ghanbarzadeh-Dagheyan*, Kalloor Joseph Francis, Cyrille Mooij, Stefan van der Stel, Mithun Kuniyil Ajith Singh, Theo Ruers

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
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Abstract

Colorectal cancer claimed nearly 1 million lives in 2022. According to World Health Organization, the prevalence and mortality rates of this disease are on the rise in the world, mainly due to an unhealthy diet, low in fiber. Recently, neoadjuvant therapy, which is a combination of chemo- and radiotherapy, has gained more attention over radical surgery for responsive patients. This is because if the patient responds excellently to neoadjuvant therapy, through monitoring, radical surgery could be avoided, saving the patient's organ and bettering their quality of life. However, presently, monitoring is limited using MRI and colonoscopy, making decisions about the patient's status difficult after therapy. New modalities such as photoacoustic (PA) imaging may help improve the monitoring by distinguishing between malignant and healthy or fibrotic tissue. In this work, we carry out a preliminary study on the use of LED-based PA imaging on colorectal samples ex vivo, in a preclinical setting. Our analysis shows that the PA image intensity is lower in the malignant tissue than the fatty tissue. However, our results are inconclusive about the difference between tumor and healthy colorectal tissue due to limited data and the effect of depth on the PA signal. For future research, collecting more data and the use of a tunable laser source are recommended.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2024
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510669437
DOIs
Publication statusPublished - 2024
EventPhotons Plus Ultrasound: Imaging and Sensing 2024 - San Francisco, United States
Duration: 28 Jan 202431 Jan 2024

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume12842
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2024
Country/TerritoryUnited States
CitySan Francisco
Period28/01/2431/01/24

Keywords

  • 2024 OA procedure
  • Colorectal cancer
  • Photoacoustic imaging
  • Ultrasound imaging
  • Cancer detection

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