Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2245-2260 |
| Number of pages | 16 |
| Journal | Biomedical optics express |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2017 |
Fingerprint
Keywords
- IR-104618
- METIS-321943
Cite this
}
Photoacoustic reflection artifact reduction using photoacoustic-guided focused ultrasound : comparison between plane-wave and element-by-element synthetic backpropagation approach. / Kuniyil Ajith Singh, M.; Jaeger, M.; Frenz, M.; Steenbergen, Wiendelt.
In: Biomedical optics express, Vol. 8, No. 4, 2017, p. 2245-2260.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Photoacoustic reflection artifact reduction using photoacoustic-guided focused ultrasound
T2 - comparison between plane-wave and element-by-element synthetic backpropagation approach
AU - Kuniyil Ajith Singh, M.
AU - Jaeger, M.
AU - Frenz, M.
AU - Steenbergen, Wiendelt
N1 - Open access
PY - 2017
Y1 - 2017
N2 - Reflection artifacts caused by acoustic inhomogeneities constitute a major problem in epi-mode biomedical photoacoustic imaging. Photoacoustic transients from the skin and superficial optical absorbers traverse into the tissue and reflect off echogenic structures to generate reflection artifacts. These artifacts cause difficulties in the interpretation of images and reduce contrast and imaging depth. We recently developed a method called PAFUSion (photoacoustic-guided focused ultrasound) to circumvent the problem of reflection artifacts in photoacoustic imaging. We already demonstrated that the photoacoustic signals can be backpropagated using synthetic aperture pulse-echo data for identifying and reducing reflection artifacts in vivo. In this work, we propose an alternative variant of PAFUSion in which synthetic backpropagation of photoacoustic signals is based on multi-angled plane-wave ultrasound measurements. We implemented plane-wave and synthetic aperture PAFUSion in a handheld ultrasound/photoacoustic imaging system and demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on a human finger using both approaches. Our results suggest that, while both approaches are equivalent in terms of artifact reduction efficiency, plane-wave PAFUSion requires less pulse echo acquisitions when the skin absorption is the main cause of reflection artifacts.
AB - Reflection artifacts caused by acoustic inhomogeneities constitute a major problem in epi-mode biomedical photoacoustic imaging. Photoacoustic transients from the skin and superficial optical absorbers traverse into the tissue and reflect off echogenic structures to generate reflection artifacts. These artifacts cause difficulties in the interpretation of images and reduce contrast and imaging depth. We recently developed a method called PAFUSion (photoacoustic-guided focused ultrasound) to circumvent the problem of reflection artifacts in photoacoustic imaging. We already demonstrated that the photoacoustic signals can be backpropagated using synthetic aperture pulse-echo data for identifying and reducing reflection artifacts in vivo. In this work, we propose an alternative variant of PAFUSion in which synthetic backpropagation of photoacoustic signals is based on multi-angled plane-wave ultrasound measurements. We implemented plane-wave and synthetic aperture PAFUSion in a handheld ultrasound/photoacoustic imaging system and demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on a human finger using both approaches. Our results suggest that, while both approaches are equivalent in terms of artifact reduction efficiency, plane-wave PAFUSion requires less pulse echo acquisitions when the skin absorption is the main cause of reflection artifacts.
KW - IR-104618
KW - METIS-321943
U2 - 10.1364/BOE.8.002245
DO - 10.1364/BOE.8.002245
M3 - Article
VL - 8
SP - 2245
EP - 2260
JO - Biomedical optics express
JF - Biomedical optics express
SN - 2156-7085
IS - 4
ER -