Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (Adv. Mater. 28/2024)

In article number 2308949 by Maik Schot, Jeroen Leijten, and co-workers, engineered living tissues containing high density capillary networks are fabricated in a clinically scalable manner. This is achieved by photo-annealing living microtissues, which are mass produced using in-air microfluidics. The resulting microporous yet monolithic living tissues are directly perfusable and offer micrometer-scale diffusive length regardless of tissue size, enabling unprecedented exchange rates for nutrients, waste products, and stimulating molecules to allow for the upscaling of living matter.