Physical behavior and associations with health outcomes in operable NSCLC patients: A prospective study

J. G.(Josien) Timmerman* (Corresponding Author), M. G.H.(Marit) Dekker-van Weering (Corresponding Author), M. W.J.M.(Michel) Wouters (Corresponding Author), Martijn M. Stuiver (Corresponding Author), W. (Wanda) de Kanter (Corresponding Author), M. M.R.(Miriam) Vollenbroek-Hutten

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    1 Citation (Scopus)
    28 Downloads (Pure)

    Abstract

    Objectives: Our objectives were to 1) characterize daily physical behavior of operable non-small cell lung cancer (NSCLC) patients, from preoperative to six months postoperative using accelerometry, and explore if physical behavior preoperative or one month postoperative is associated with better health outcomes at six months postoperative. Methods: A prospective study with 23 patients (13 female) diagnosed with primary NSCLC and scheduled for curative lung resection was performed. Outcome measures were assessed two weeks preoperative, and one, three and six months postoperative, and included accelerometer-derived physical behavior measures and the following health outcomes: six minute walking distance (6MWD), questionnaires concerning health-related quality of life (HRQOL), fatigue and distress. Results: On group average, physical behavior showed significant changes over time. Physical behavior worsened following surgery, but improved between one and six months postoperative, almost reaching preoperative levels. However, physical behavior showed high variability between patients in both amount as well as change over time. More time in moderate-to-vigorous physical activity in bouts of 10 min or longer in the first month postoperative was significantly associated with better 6MWD, HRQOL, distress, and fatigue at six months postoperative. Conclusion: As expected, curative lung resection impacts physical behavior. Patients who were more active in the first month following surgery reported better health outcome six months postoperative. The large variability in activity patterns over time observed between patients, suggests that physical behavior ‘profiling’ through detailed monitoring of physical behavior could facilitate tailored goal setting in interventions that target change in physical behavior.

    Original languageEnglish
    Pages (from-to)91-98
    Number of pages8
    JournalLung cancer
    Volume119
    DOIs
    Publication statusPublished - 1 May 2018

    Fingerprint

    Non-Small Cell Lung Carcinoma
    Prospective Studies
    Health
    Fatigue
    Quality of Life
    Accelerometry
    Lung
    Walking
    Outcome Assessment (Health Care)
    Exercise

    Keywords

    • UT-Hybrid-D
    • Lung cancer
    • Lung resection
    • Physical behavior
    • Quality of life
    • Sedentary behavior
    • Accelerometry

    Cite this

    Timmerman, J. G.(Josien) ; Dekker-van Weering, M. G.H.(Marit) ; Wouters, M. W.J.M.(Michel) ; Stuiver, Martijn M. ; de Kanter, W. (Wanda) ; Vollenbroek-Hutten, M. M.R.(Miriam). / Physical behavior and associations with health outcomes in operable NSCLC patients : A prospective study. In: Lung cancer. 2018 ; Vol. 119. pp. 91-98.
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    title = "Physical behavior and associations with health outcomes in operable NSCLC patients: A prospective study",
    abstract = "Objectives: Our objectives were to 1) characterize daily physical behavior of operable non-small cell lung cancer (NSCLC) patients, from preoperative to six months postoperative using accelerometry, and explore if physical behavior preoperative or one month postoperative is associated with better health outcomes at six months postoperative. Methods: A prospective study with 23 patients (13 female) diagnosed with primary NSCLC and scheduled for curative lung resection was performed. Outcome measures were assessed two weeks preoperative, and one, three and six months postoperative, and included accelerometer-derived physical behavior measures and the following health outcomes: six minute walking distance (6MWD), questionnaires concerning health-related quality of life (HRQOL), fatigue and distress. Results: On group average, physical behavior showed significant changes over time. Physical behavior worsened following surgery, but improved between one and six months postoperative, almost reaching preoperative levels. However, physical behavior showed high variability between patients in both amount as well as change over time. More time in moderate-to-vigorous physical activity in bouts of 10 min or longer in the first month postoperative was significantly associated with better 6MWD, HRQOL, distress, and fatigue at six months postoperative. Conclusion: As expected, curative lung resection impacts physical behavior. Patients who were more active in the first month following surgery reported better health outcome six months postoperative. The large variability in activity patterns over time observed between patients, suggests that physical behavior ‘profiling’ through detailed monitoring of physical behavior could facilitate tailored goal setting in interventions that target change in physical behavior.",
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    author = "Timmerman, {J. G.(Josien)} and {Dekker-van Weering}, {M. G.H.(Marit)} and Wouters, {M. W.J.M.(Michel)} and Stuiver, {Martijn M.} and {de Kanter}, {W. (Wanda)} and Vollenbroek-Hutten, {M. M.R.(Miriam)}",
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    Physical behavior and associations with health outcomes in operable NSCLC patients : A prospective study. / Timmerman, J. G.(Josien) (Corresponding Author); Dekker-van Weering, M. G.H.(Marit) (Corresponding Author); Wouters, M. W.J.M.(Michel) (Corresponding Author); Stuiver, Martijn M. (Corresponding Author); de Kanter, W. (Wanda) (Corresponding Author); Vollenbroek-Hutten, M. M.R.(Miriam).

    In: Lung cancer, Vol. 119, 01.05.2018, p. 91-98.

    Research output: Contribution to journalArticleAcademicpeer-review

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    T1 - Physical behavior and associations with health outcomes in operable NSCLC patients

    T2 - A prospective study

    AU - Timmerman, J. G.(Josien)

    AU - Dekker-van Weering, M. G.H.(Marit)

    AU - Wouters, M. W.J.M.(Michel)

    AU - Stuiver, Martijn M.

    AU - de Kanter, W. (Wanda)

    AU - Vollenbroek-Hutten, M. M.R.(Miriam)

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    N2 - Objectives: Our objectives were to 1) characterize daily physical behavior of operable non-small cell lung cancer (NSCLC) patients, from preoperative to six months postoperative using accelerometry, and explore if physical behavior preoperative or one month postoperative is associated with better health outcomes at six months postoperative. Methods: A prospective study with 23 patients (13 female) diagnosed with primary NSCLC and scheduled for curative lung resection was performed. Outcome measures were assessed two weeks preoperative, and one, three and six months postoperative, and included accelerometer-derived physical behavior measures and the following health outcomes: six minute walking distance (6MWD), questionnaires concerning health-related quality of life (HRQOL), fatigue and distress. Results: On group average, physical behavior showed significant changes over time. Physical behavior worsened following surgery, but improved between one and six months postoperative, almost reaching preoperative levels. However, physical behavior showed high variability between patients in both amount as well as change over time. More time in moderate-to-vigorous physical activity in bouts of 10 min or longer in the first month postoperative was significantly associated with better 6MWD, HRQOL, distress, and fatigue at six months postoperative. Conclusion: As expected, curative lung resection impacts physical behavior. Patients who were more active in the first month following surgery reported better health outcome six months postoperative. The large variability in activity patterns over time observed between patients, suggests that physical behavior ‘profiling’ through detailed monitoring of physical behavior could facilitate tailored goal setting in interventions that target change in physical behavior.

    AB - Objectives: Our objectives were to 1) characterize daily physical behavior of operable non-small cell lung cancer (NSCLC) patients, from preoperative to six months postoperative using accelerometry, and explore if physical behavior preoperative or one month postoperative is associated with better health outcomes at six months postoperative. Methods: A prospective study with 23 patients (13 female) diagnosed with primary NSCLC and scheduled for curative lung resection was performed. Outcome measures were assessed two weeks preoperative, and one, three and six months postoperative, and included accelerometer-derived physical behavior measures and the following health outcomes: six minute walking distance (6MWD), questionnaires concerning health-related quality of life (HRQOL), fatigue and distress. Results: On group average, physical behavior showed significant changes over time. Physical behavior worsened following surgery, but improved between one and six months postoperative, almost reaching preoperative levels. However, physical behavior showed high variability between patients in both amount as well as change over time. More time in moderate-to-vigorous physical activity in bouts of 10 min or longer in the first month postoperative was significantly associated with better 6MWD, HRQOL, distress, and fatigue at six months postoperative. Conclusion: As expected, curative lung resection impacts physical behavior. Patients who were more active in the first month following surgery reported better health outcome six months postoperative. The large variability in activity patterns over time observed between patients, suggests that physical behavior ‘profiling’ through detailed monitoring of physical behavior could facilitate tailored goal setting in interventions that target change in physical behavior.

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    KW - Lung cancer

    KW - Lung resection

    KW - Physical behavior

    KW - Quality of life

    KW - Sedentary behavior

    KW - Accelerometry

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