Physiological stress induces the metastasis marker AGR2 in breast cancer cells

D.R. Zweitzig; D.A. Smirnov; M.C. Connelly; L.W.M.M. Terstappen; S.M. O'Hara; E. Moran

doi:10.1007/s11010-007-9562-y

Physiological stress induces the metastasis marker AGR2 in breast cancer cells

D.R. Zweitzig, D.A. Smirnov, M.C. Connelly, L.W.M.M. Terstappen, S.M. O'Hara, E. Moran

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was investigated. These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood. The present results identify novel physiological parameters likely to contribute to AGR2 induction in situ.

Original language	English
Pages (from-to)	255-260
Journal	Molecular and Cellular Biochemistry
Volume	306
DOIs	https://doi.org/10.1007/s11010-007-9562-y
Publication status	Published - 2007
Externally published	Yes

Keywords

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abstract = "As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was investigated. These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood. The present results identify novel physiological parameters likely to contribute to AGR2 induction in situ.",

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AU - Zweitzig, D.R.

AU - Smirnov, D.A.

AU - Connelly, M.C.

AU - Terstappen, L.W.M.M.

AU - O'Hara, S.M.

AU - Moran, E.

PY - 2007

Y1 - 2007

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AB - As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was investigated. These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood. The present results identify novel physiological parameters likely to contribute to AGR2 induction in situ.

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DO - 10.1007/s11010-007-9562-y

M3 - Article

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SP - 255

EP - 260

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

ER -

Physiological stress induces the metastasis marker AGR2 in breast cancer cells

Abstract

Keywords

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