Planar Nanoneedles on-chip for intracellular measurements

Jurjen Emmelkamp; Johannes G.E. Gardeniers; Helene Andersson; Albert van den Berg

Planar Nanoneedles on-chip for intracellular measurements

Jurjen Emmelkamp, Johannes G.E. Gardeniers, Helene Andersson, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.

Original language	Undefined
Title of host publication	Proceedings of microTAS 2005 Conference
Editors	K.F Jensen, J. Han, D.J. Harrison, J. Voldman
Place of Publication	Boston, Massachusetts
Publisher	Transducers Research Foundation, Inc.
Pages	400-402
Number of pages	3
ISBN (Print)	0-9743611-1-9
Publication status	Published - 9 Oct 2005
Event	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 - Boston, United States Duration: 9 Oct 2005 → 13 Oct 2005 Conference number: 9

Publication series

Name
Publisher	Transducers Research Foundation, Inc.
Volume	1

Conference

Conference	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005
Abbreviated title	MicroTAS
Country/Territory	United States
City	Boston
Period	9/10/05 → 13/10/05

Keywords

IR-52862
METIS-224688

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

Emmelkamp-MicroTAS2005

Cite this

@inproceedings{37c0c9161106482ea9270aed53b41c19,

title = "Planar Nanoneedles on-chip for intracellular measurements",

abstract = "We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.",

keywords = "IR-52862, METIS-224688",

author = "Jurjen Emmelkamp and Gardeniers, {Johannes G.E.} and Helene Andersson and {van den Berg}, Albert",

year = "2005",

month = oct,

day = "9",

language = "Undefined",

isbn = "0-9743611-1-9",

publisher = "Transducers Research Foundation, Inc.",

pages = "400--402",

editor = "K.F Jensen and J. Han and D.J. Harrison and J. Voldman",

booktitle = "Proceedings of microTAS 2005 Conference",

note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",

}

Emmelkamp, J, Gardeniers, JGE, Andersson, H & van den Berg, A 2005, Planar Nanoneedles on-chip for intracellular measurements. in KF Jensen, J Han, DJ Harrison & J Voldman (eds), Proceedings of microTAS 2005 Conference. Transducers Research Foundation, Inc., Boston, Massachusetts, pp. 400-402, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005, Boston, Massachusetts, United States, 9/10/05.

Planar Nanoneedles on-chip for intracellular measurements. / Emmelkamp, Jurjen; Gardeniers, Johannes G.E.; Andersson, Helene et al.
Proceedings of microTAS 2005 Conference. ed. / K.F Jensen; J. Han; D.J. Harrison; J. Voldman. Boston, Massachusetts: Transducers Research Foundation, Inc., 2005. p. 400-402.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Planar Nanoneedles on-chip for intracellular measurements

AU - Emmelkamp, Jurjen

AU - Gardeniers, Johannes G.E.

AU - Andersson, Helene

AU - van den Berg, Albert

N1 - Conference code: 9

PY - 2005/10/9

Y1 - 2005/10/9

N2 - We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.

AB - We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.

KW - IR-52862

KW - METIS-224688

M3 - Conference contribution

SN - 0-9743611-1-9

SP - 400

EP - 402

BT - Proceedings of microTAS 2005 Conference

A2 - Jensen, K.F

A2 - Han, J.

A2 - Harrison, D.J.

A2 - Voldman, J.

PB - Transducers Research Foundation, Inc.

CY - Boston, Massachusetts

T2 - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005

Y2 - 9 October 2005 through 13 October 2005

ER -