Planar Nanoneedles on-chip for intracellular measurements

Jurjen Emmelkamp, Johannes G.E. Gardeniers, Helene Andersson, Albert van den Berg

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Abstract

We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.
Original languageUndefined
Title of host publicationProceedings of microTAS 2005 Conference
EditorsK.F Jensen, J. Han, D.J. Harrison, J. Voldman
Place of PublicationBoston, Massachusetts
PublisherTransducers Research Foundation, Inc.
Pages400-402
Number of pages3
ISBN (Print)0-9743611-1-9
Publication statusPublished - 9 Oct 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 - Boston, United States
Duration: 9 Oct 200513 Oct 2005
Conference number: 9

Publication series

Name
PublisherTransducers Research Foundation, Inc.
Volume1

Conference

Conference9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005
Abbreviated titleMicroTAS
CountryUnited States
CityBoston
Period9/10/0513/10/05

Keywords

  • IR-52862
  • METIS-224688

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