Planar Nanoneedles on-chip for intracellular measurements

Jurjen Emmelkamp, Johannes G.E. Gardeniers, Helene Andersson, Albert van den Berg

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Abstract

We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.
Original languageUndefined
Title of host publicationMicroTAS 2005 Conference -9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of PublicationSan Diego, CA, USA
PublisherTransducer Research Foundation
Pages400-402
Number of pages3
ISBN (Print)9780444511003
Publication statusPublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 - Boston, United States
Duration: 9 Oct 200513 Oct 2005
Conference number: 9

Publication series

NameMicro total analysis systems 2005
PublisherTransducer Research Foundation

Conference

Conference9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005
Abbreviated titleMicroTAS
CountryUnited States
CityBoston
Period9/10/0513/10/05

Keywords

  • Micro machining
  • Nanofluidics
  • Nanoneedles
  • intracellular
  • EWI-20071

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