Podosomes of dendritic cells facilitate antigen sampling

M.V. Baranov, M. ter Beest, I. Reinieren-Beeren, A. Cambi, Carl Figdor, G. van den Bogaart

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Abstract

Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we show that podosomes of human dendritic cells locate to spots of low physical resistance in the substrate (soft spots) where they can evolve into protrusive structures. Pathogen recognition receptors locate to these protrusive structures where they can trigger localized antigen uptake, processing and presentation to activate T-cells. Our data demonstrate a novel role in antigen sampling for the podosomes of dendritic cells
Original languageUndefined
Pages (from-to)1052-1064
Number of pages13
JournalJournal of cell science
Volume127
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-306354
  • IR-94952

Cite this

Baranov, M. V., ter Beest, M., Reinieren-Beeren, I., Cambi, A., Figdor, C., & van den Bogaart, G. (2014). Podosomes of dendritic cells facilitate antigen sampling. Journal of cell science, 127(5), 1052-1064. https://doi.org/10.1242/jcs.141226