Point of care creatinine measurement for diagnosis of renal disease using a disposable microchip

Mónica Ávila Muñoz, J. Floris, S.S. Staal, Ángel Ríos, Jan C.T. Eijkel, Albert van den Berg

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    A point-of-care device for the determination of elevated creatinine levels in blood is reported. This device potentially offers a new and simple clinical regime for the determination of creatinine that will give huge time savings and removal of several steps of determination. The test employs a disposable prefilled microchip and the handheld Medimate Multireader®. By optimizing the analytical conditions it was found that the LOD of the proposed method was 87 μM creatinine, close to the normal human serum levels that are in the range of 60 to 100 μM. A statistical analysis of the residual shows a normal distribution, indicating the absence of systematic errors in the proposed method. The test can be used to distinguish patients with renal insufficiency (creatinine levels >100 μM) from healthy persons. Long-term monitoring could furthermore distinguish between acute renal failure and chronic kidney disease by the rate of creatinine concentration rise.
    Original languageUndefined
    Pages (from-to)2956-2961
    Number of pages6
    Issue number20-21
    Publication statusPublished - 4 Aug 2013


    • EWI-24428
    • IR-89276
    • METIS-302693

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