Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

D. Kohlheyer, Jan C.T. Eijkel, Stefan Lenk, S.O. Lenk, J. Floris, S.S. Staal, Steven Staal, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.
Original languageUndefined
Title of host publicationMicro Total Analysis Systems 2009
EditorsT.S. Kim, Y-S Lee, T-D Chung, N.L. Jeon, S.H. Lee, K-Y Suh, J. Choo, Y-K Kim
Place of PublicationSan Diego
PublisherChemical and Biological Society
Pages1731-1733
Number of pages3
ISBN (Print)978-0-9798064-2-1
Publication statusPublished - 1 Nov 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009
Conference number: 13

Publication series

NamemicroTAS 2009
PublisherChemical and Biological Society
Volume2

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009
Abbreviated titleMicroTAS
CountryKorea, Republic of
CityJeju
Period1/11/095/11/09

Keywords

  • METIS-268931
  • EWI-17155
  • IR-69428

Cite this

Kohlheyer, D., Eijkel, J. C. T., Lenk, S., Lenk, S. O., Floris, J., Staal, S. S., ... van den Berg, A. (2009). Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. In T. S. Kim, Y-S. Lee, T-D. Chung, N. L. Jeon, S. H. Lee, K-Y. Suh, J. Choo, ... Y-K. Kim (Eds.), Micro Total Analysis Systems 2009 (pp. 1731-1733). (microTAS 2009; Vol. 2). San Diego: Chemical and Biological Society.
Kohlheyer, D. ; Eijkel, Jan C.T. ; Lenk, Stefan ; Lenk, S.O. ; Floris, J. ; Staal, S.S. ; Staal, Steven ; van den Berg, Albert. / Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. Micro Total Analysis Systems 2009. editor / T.S. Kim ; Y-S Lee ; T-D Chung ; N.L. Jeon ; S.H. Lee ; K-Y Suh ; J. Choo ; Y-K Kim. San Diego : Chemical and Biological Society, 2009. pp. 1731-1733 (microTAS 2009).
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abstract = "This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.",
keywords = "METIS-268931, EWI-17155, IR-69428",
author = "D. Kohlheyer and Eijkel, {Jan C.T.} and Stefan Lenk and S.O. Lenk and J. Floris and S.S. Staal and Steven Staal and {van den Berg}, Albert",
year = "2009",
month = "11",
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isbn = "978-0-9798064-2-1",
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Kohlheyer, D, Eijkel, JCT, Lenk, S, Lenk, SO, Floris, J, Staal, SS, Staal, S & van den Berg, A 2009, Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. in TS Kim, Y-S Lee, T-D Chung, NL Jeon, SH Lee, K-Y Suh, J Choo & Y-K Kim (eds), Micro Total Analysis Systems 2009. microTAS 2009, vol. 2, Chemical and Biological Society, San Diego, pp. 1731-1733, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009, Jeju, Korea, Republic of, 1/11/09.

Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. / Kohlheyer, D.; Eijkel, Jan C.T.; Lenk, Stefan; Lenk, S.O.; Floris, J.; Staal, S.S.; Staal, Steven; van den Berg, Albert.

Micro Total Analysis Systems 2009. ed. / T.S. Kim; Y-S Lee; T-D Chung; N.L. Jeon; S.H. Lee; K-Y Suh; J. Choo; Y-K Kim. San Diego : Chemical and Biological Society, 2009. p. 1731-1733 (microTAS 2009; Vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

AU - Kohlheyer, D.

AU - Eijkel, Jan C.T.

AU - Lenk, Stefan

AU - Lenk, S.O.

AU - Floris, J.

AU - Staal, S.S.

AU - Staal, Steven

AU - van den Berg, Albert

PY - 2009/11/1

Y1 - 2009/11/1

N2 - This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.

AB - This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.

KW - METIS-268931

KW - EWI-17155

KW - IR-69428

M3 - Conference contribution

SN - 978-0-9798064-2-1

T3 - microTAS 2009

SP - 1731

EP - 1733

BT - Micro Total Analysis Systems 2009

A2 - Kim, T.S.

A2 - Lee, Y-S

A2 - Chung, T-D

A2 - Jeon, N.L.

A2 - Lee, S.H.

A2 - Suh, K-Y

A2 - Choo, J.

A2 - Kim, Y-K

PB - Chemical and Biological Society

CY - San Diego

ER -

Kohlheyer D, Eijkel JCT, Lenk S, Lenk SO, Floris J, Staal SS et al. Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. In Kim TS, Lee Y-S, Chung T-D, Jeon NL, Lee SH, Suh K-Y, Choo J, Kim Y-K, editors, Micro Total Analysis Systems 2009. San Diego: Chemical and Biological Society. 2009. p. 1731-1733. (microTAS 2009).