Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

D. Kohlheyer; Jan C.T. Eijkel; Stefan Lenk; Arjan Floris; Steven Staal; Albert van den Berg

Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

D. Kohlheyer, Jan C.T. Eijkel, Stefan Lenk, Arjan Floris, Steven Staal, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

2 Citations (Scopus)

4 Downloads (Pure)

Abstract

This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.

Original language	English
Title of host publication	Micro Total Analysis Systems 2009
Editors	T.S. Kim, Y-S Lee, T-D Chung, N.L. Jeon, S.H. Lee, K-Y Suh, J. Choo, Y-K Kim
Place of Publication	San Diego
Publisher	Chemical and Biological Society
Pages	1731-1733
Number of pages	3
ISBN (Print)	978-0-9798064-2-1
Publication status	Published - 1 Nov 2009
Event	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of Duration: 1 Nov 2009 → 5 Nov 2009 Conference number: 13

Publication series

Name	microTAS 2009
Publisher	Chemical and Biological Society
Volume	2

Conference

Conference	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009
Abbreviated title	MicroTAS
Country/Territory	Korea, Republic of
City	Jeju
Period	1/11/09 → 5/11/09

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Kohlheyer, D., Eijkel, J. C. T., Lenk, S., Floris, A., Staal, S., & van den Berg, A. (2009). Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. In T. S. Kim, Y-S. Lee, T-D. Chung, N. L. Jeon, S. H. Lee, K-Y. Suh, J. Choo, & Y-K. Kim (Eds.), Micro Total Analysis Systems 2009 (pp. 1731-1733). (microTAS 2009; Vol. 2). Chemical and Biological Society.

Kohlheyer, D. ; Eijkel, Jan C.T. ; Lenk, Stefan et al. / Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. Micro Total Analysis Systems 2009. editor / T.S. Kim ; Y-S Lee ; T-D Chung ; N.L. Jeon ; S.H. Lee ; K-Y Suh ; J. Choo ; Y-K Kim. San Diego : Chemical and Biological Society, 2009. pp. 1731-1733 (microTAS 2009).

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title = "Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip",

abstract = "This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient{\textquoteright}s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.",

author = "D. Kohlheyer and Eijkel, {Jan C.T.} and Stefan Lenk and Arjan Floris and Steven Staal and {van den Berg}, Albert",

year = "2009",

month = nov,

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language = "English",

isbn = "978-0-9798064-2-1",

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booktitle = "Micro Total Analysis Systems 2009",

note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009, MicroTAS ; Conference date: 01-11-2009 Through 05-11-2009",

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Kohlheyer, D, Eijkel, JCT, Lenk, S, Floris, A, Staal, S & van den Berg, A 2009, Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. in TS Kim, Y-S Lee, T-D Chung, NL Jeon, SH Lee, K-Y Suh, J Choo & Y-K Kim (eds), Micro Total Analysis Systems 2009. microTAS 2009, vol. 2, Chemical and Biological Society, San Diego, pp. 1731-1733, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009, Jeju, Korea, Republic of, 1/11/09.

Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. / Kohlheyer, D.; Eijkel, Jan C.T.; Lenk, Stefan et al.

Micro Total Analysis Systems 2009. ed. / T.S. Kim; Y-S Lee; T-D Chung; N.L. Jeon; S.H. Lee; K-Y Suh; J. Choo; Y-K Kim. San Diego : Chemical and Biological Society, 2009. p. 1731-1733 (microTAS 2009; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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T1 - Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

AU - Kohlheyer, D.

AU - Eijkel, Jan C.T.

AU - Lenk, Stefan

AU - Floris, Arjan

AU - Staal, Steven

AU - van den Berg, Albert

N1 - Conference code: 13

PY - 2009/11/1

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N2 - This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.

AB - This paper describes a microfluidic capillary electrophoresis device with integrated conductivity detection. The device satisfies all major requirements for pointof- care testing, i.e., simple handling, low sample volume, fast measurements, clear readout, and inexpensive disposable cartridge usage. The system is currently being utilized and commercialized for monitoring lithium in whole blood, however, can potentially be applied to various other ions present in blood, urine or other bodily fluids. The chip contains a single inlet only and will be shipped prefilled with background electrolyte, sealed and blistered; ready for use at the patient’s place. A single droplet of blood is required to be placed inside the cartridge to perform the analysis typically within a couple of minutes.

M3 - Conference contribution

SN - 978-0-9798064-2-1

T3 - microTAS 2009

SP - 1731

EP - 1733

BT - Micro Total Analysis Systems 2009

A2 - Kim, T.S.

A2 - Lee, Y-S

A2 - Chung, T-D

A2 - Jeon, N.L.

A2 - Lee, S.H.

A2 - Suh, K-Y

A2 - Choo, J.

A2 - Kim, Y-K

PB - Chemical and Biological Society

CY - San Diego

T2 - 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009

Y2 - 1 November 2009 through 5 November 2009

ER -

Kohlheyer D, Eijkel JCT, Lenk S, Floris A, Staal S, van den Berg A. Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip. In Kim TS, Lee Y-S, Chung T-D, Jeon NL, Lee SH, Suh K-Y, Choo J, Kim Y-K, editors, Micro Total Analysis Systems 2009. San Diego: Chemical and Biological Society. 2009. p. 1731-1733. (microTAS 2009).

Point-of-care lithium monitoring in whole blood using a disposable, prefilled and ready-to-use capillary electrophoresis microchip

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