Polyactive as a bone-filler in a beagle dog model

G.J. Meijer, A. van Dooren, M.L. Gallard, R. Dalmeijer, C. de Putter, R. Koole, Clemens van Blitterswijk

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Calcification is a crucial step in the bone-bonding mechanism of PEO/PBT hydrogel copolymers (Polyactive®), a new generation of bone-fillers. A beagle dog study was conducted to determine whether the preoperative presence of a calcium phosphate layer (precalcification) on a PEO/PBT 80/20 copolymer would further increase the bone-bonding rate. Standard bone cavities were filled with either precalcified or nonprecalcified porous cylindric PEO/PBT 80/20 implants, or hydroxyapatite granules held together with PEO/PBT 70/30, or were left unfilled. A significantly higher percentage of mineralized component was present in the cavities filled with the precalcified PEO/PBT 80/20 copolymer than in the control defects. As a result of swelling by fluid-uptake, the press-fit inserted copolymer implants showed a significant reduction in pore size, thus preventing optimal bone ingrowth. Both precalcification of the copolymer and underfilling of the defect, to create space for the copolymer to increase in diameter, stimulate postoperative calcification and bone in-growth in PEO/PBT 80/20 copolymers.
Original languageUndefined
Pages (from-to)210-216
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number3
Publication statusPublished - 1996


  • IR-57246

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