Polyelectrolyte complex micelles as wrapping for enzymes

Saskia Lindhoud

Research output: Thesis › PhD Thesis - Research external, graduation external › Academic

59 Downloads (Pure)

Abstract

During this PhD-project the applicability of polyelectrolyte complex micelles as "wrapping" for enzymes has been explored. Several aspects of this interdisciplinary topic have been addressed. The approach was as follows: rst, the preparation protocol of the micelles was studied (chapter 2-4), followed by the stability of the micelles against disintegration by salt (chapter 5 and 6). In chapter 7 self consistent eld calculations were performed to obtain information about the free energy associated with the incorporation of enzymes in polyelectrolyte complex micelles. The information gathered in these seven chapters was very useful for the interpretation of the enzymatic activity of lipase incorporated in these micelles. The results of that study are reported in chapter 8. In this summary the main ndings are discussed per chapter.
Original languageEnglish
Awarding Institution
  • Wageningen University & Research
Supervisors/Advisors
  • Cohen Stuart, M.A., Supervisor
  • Norde, Willem, Supervisor, External person
  • de Vries, R.J., Co-Supervisor
Award date16 Sep 2009
Publisher
Print ISBNs978-90-8585-438-8
Publication statusPublished - 16 Sep 2009
Externally publishedYes

Fingerprint

Micelles
Polyelectrolytes
Enzymes
Disintegration
Lipase
Free energy
Salts

Keywords

  • IR-99771

Cite this

Lindhoud, Saskia. / Polyelectrolyte complex micelles as wrapping for enzymes. Wageningen Universiteit, 2009. 207 p.
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Lindhoud, S 2009, 'Polyelectrolyte complex micelles as wrapping for enzymes', Wageningen University & Research.

Polyelectrolyte complex micelles as wrapping for enzymes. / Lindhoud, Saskia.

Wageningen Universiteit, 2009. 207 p.

Research output: Thesis › PhD Thesis - Research external, graduation external › Academic

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T1 - Polyelectrolyte complex micelles as wrapping for enzymes

AU - Lindhoud, Saskia

PY - 2009/9/16

Y1 - 2009/9/16

N2 - During this PhD-project the applicability of polyelectrolyte complex micelles as "wrapping" for enzymes has been explored. Several aspects of this interdisciplinary topic have been addressed. The approach was as follows: rst, the preparation protocol of the micelles was studied (chapter 2-4), followed by the stability of the micelles against disintegration by salt (chapter 5 and 6). In chapter 7 self consistent eld calculations were performed to obtain information about the free energy associated with the incorporation of enzymes in polyelectrolyte complex micelles. The information gathered in these seven chapters was very useful for the interpretation of the enzymatic activity of lipase incorporated in these micelles. The results of that study are reported in chapter 8. In this summary the main ndings are discussed per chapter.

AB - During this PhD-project the applicability of polyelectrolyte complex micelles as "wrapping" for enzymes has been explored. Several aspects of this interdisciplinary topic have been addressed. The approach was as follows: rst, the preparation protocol of the micelles was studied (chapter 2-4), followed by the stability of the micelles against disintegration by salt (chapter 5 and 6). In chapter 7 self consistent eld calculations were performed to obtain information about the free energy associated with the incorporation of enzymes in polyelectrolyte complex micelles. The information gathered in these seven chapters was very useful for the interpretation of the enzymatic activity of lipase incorporated in these micelles. The results of that study are reported in chapter 8. In this summary the main ndings are discussed per chapter.

KW - IR-99771

M3 - PhD Thesis - Research external, graduation external

SN - 978-90-8585-438-8

PB - Wageningen Universiteit

ER -

Lindhoud S. Polyelectrolyte complex micelles as wrapping for enzymes. Wageningen Universiteit, 2009. 207 p.

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