Polyethylene glycol-grafted polystyrene particles

Fenghua Meng, G.H.M. Engbers, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Abstract

Densely pegylated particles that can serve as a model system for artificial cells were prepared by covalently grafting amino polyethylene glycol (PEG, molecular weight 3400 or 5000) onto carboxyl polystyrene particles (PS-COOH) using carbodiimide chemistry. PEG-modified particles (PS-PEG) were characterized by determination of the PEG surface concentration, -potential, size, and morphology. Under optimized grafting conditions, a dense brush-like PEG layer was formed. A PEG surface concentration of approximately 60 pmol/cm2, corresponding with an average distance between grafted PEG chains of 17 Å can be realized. It was shown that grafting of PEG onto PS-COOH reduced the adsorption of proteins from human plasma (85 vol %) in phosphate-buffered saline up to 90%
Original languageUndefined
Pages (from-to)49-58
JournalJournal of biomedical materials research. Part A
Volume70A
Issue number1
DOIs
Publication statusPublished - 2004

Keywords

  • IR-71380
  • METIS-223580

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