Polymeric carrier systems for siRNA delivery

P. Vader, L.J. van der Aa, Gerrit Storm, R.M. Schiffelers, J.F.J. Engbersen

Research output: Contribution to journalReview articleAcademicpeer-review

24 Citations (Scopus)

Abstract

RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.
Original languageEnglish
Pages (from-to)108-119
JournalCurrent topics in medicinal chemistry
Volume12
Issue number2
DOIs
Publication statusPublished - 2012

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