Purpose: The aim of this study was to design and build porous microstructures with shape memory behaviour using biodegradable poly(D,L-lactide-co-trimethylene carbonate) dimethacrylate macromers. These microstructures could be advantageous for tissue engineering and other advanced biomedical applications. Methods: Porous structures with a gyroid pore network architecture showing average pore sizes of 930 µm and complete pore interconnectivity were prepared by stereolithography. Built structures were characterized by Micro-computed tomography (µ-CT). Shape recovery and shape fixity of microstructures after 40% and 70% compression were evaluated. Results: At 37 °C the flexible structures showed compression modulus values of 60 KPa and could be fully compressed. Thermal analysis showed that the built networks were amorphous with Tg values of 23 °C. After compression to 40 and 70%, shape fixity and shape recovery of the structures at respectively 0 °C and 37 °C was almost quantitative. Conclusions: The well-defined pore network characteristics and the shape-memory properties of these structures allow their use as deployable tissue engineering scaffolds.
|Journal||Journal of applied biomaterials and functional materials|
|Publication status||Published - 13 Dec 2012|
Sharifi, S., Blanquer, S., & Grijpma, D. W. (2012). Polymeric microstructures with shape-memory properties for biomedical use built by stereolithography. Journal of applied biomaterials and functional materials, 10(3), 280-286. https://doi.org/10.5301/JABFM.2012.10367