Polymeric Nanogels with Tailorable Degradation Behavior

Yinan Chen, Mies J. van Steenbergen, Dandan Li, Joep B. van de Dikkenberg, Twan Gerardus Gertudis Maria Lammers, Cornelis F. van Nostrum, Josbert Maarten Metselaar, Wim E. Hennink

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Abstract

The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.
Original languageEnglish
Pages (from-to)1122-1137
JournalMacromolecular bioscience
Volume16
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • METIS-321006
  • IR-103533

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