Polymeric Nanogels with Tailorable Degradation Behavior

Yinan Chen; Mies J. van Steenbergen; Dandan Li; Joep B. van de Dikkenberg; Twan Gerardus Gertudis Maria Lammers; Cornelis F. van Nostrum; Josbert Maarten Metselaar; Wim E. Hennink

doi:10.1002/mabi.201600031

Polymeric Nanogels with Tailorable Degradation Behavior

Yinan Chen, Mies J. van Steenbergen, Dandan Li, Joep B. van de Dikkenberg, Twan Gerardus Gertudis Maria Lammers, Cornelis F. van Nostrum, Josbert Maarten Metselaar, Wim E. Hennink

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Abstract

The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.

Original language	English
Pages (from-to)	1122-1137
Journal	Macromolecular bioscience
Volume	16
Issue number	8
DOIs	https://doi.org/10.1002/mabi.201600031
Publication status	Published - 2016

Keywords

METIS-321006
IR-103533

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10.1002/mabi.201600031

1-s2.0-S0966636217300383-main

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@article{2c428f5c433b4695be4cd81a33404162,

title = "Polymeric Nanogels with Tailorable Degradation Behavior",

abstract = "The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.",

keywords = "METIS-321006, IR-103533",

author = "Yinan Chen and {van Steenbergen}, {Mies J.} and Dandan Li and {van de Dikkenberg}, {Joep B.} and Lammers, {Twan Gerardus Gertudis Maria} and {van Nostrum}, {Cornelis F.} and Metselaar, {Josbert Maarten} and Hennink, {Wim E.}",

year = "2016",

doi = "10.1002/mabi.201600031",

language = "English",

volume = "16",

pages = "1122--1137",

journal = "Macromolecular bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "8",

}

TY - JOUR

T1 - Polymeric Nanogels with Tailorable Degradation Behavior

AU - Chen, Yinan

AU - van Steenbergen, Mies J.

AU - Li, Dandan

AU - van de Dikkenberg, Joep B.

AU - Lammers, Twan Gerardus Gertudis Maria

AU - van Nostrum, Cornelis F.

AU - Metselaar, Josbert Maarten

AU - Hennink, Wim E.

PY - 2016

Y1 - 2016

N2 - The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.

AB - The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.

KW - METIS-321006

KW - IR-103533

U2 - 10.1002/mabi.201600031

DO - 10.1002/mabi.201600031

M3 - Article

VL - 16

SP - 1122

EP - 1137

JO - Macromolecular bioscience

JF - Macromolecular bioscience

SN - 1616-5187

IS - 8

ER -

Polymeric Nanogels with Tailorable Degradation Behavior

Abstract

Keywords

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