Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains

Myungeun Seo, Benjamin J. Beck, Jos Marie Johannes Paulusse, Craig J. Hawker, Sang Youl Kim

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Novel polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by noncovalent cross-linking of dendritic self-complementary hydrogen-bonding units (SHB). Random copolymers containing SHB units, poly[(methyl methacrylate)-r-2-((3,5-bis(4-carbamoyl-3-(trifluoromethyl)phenoxy)benzyloxy)carbonylamino)ethyl methacrylate] (A1, A2), were synthesized with various incorporation ratios by reversible addition−fragmentation chain transfer (RAFT) polymerization. Dramatically different behavior was observed depending on the level of incorporation of the supramolecular units. At high loadings of A2 (6% SHB incorporation), intramolecular chain collapse is favored, resulting in the formation of well-defined polymer nanoparticles, which were characterized by scanning force microscopy (SFM), dynamic light scattering (DLS), and viscosity studies. In contrast, analysis of copolymer A1 (1% SHB incorporation) revealed that chain collapse occurred primarily through intermolecular interactions leading to large aggregates.
Original languageEnglish
Pages (from-to)6413-6418
Number of pages6
Issue number17
Publication statusPublished - 2008


  • IR-99608


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