Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains

Myungeun Seo, Benjamin J. Beck, Jos Marie Johannes Paulusse, Craig J. Hawker, Sang Youl Kim

Research output: Contribution to journalArticleAcademic

116 Citations (Scopus)

Abstract

Novel polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by noncovalent cross-linking of dendritic self-complementary hydrogen-bonding units (SHB). Random copolymers containing SHB units, poly[(methyl methacrylate)-r-2-((3,5-bis(4-carbamoyl-3-(trifluoromethyl)phenoxy)benzyloxy)carbonylamino)ethyl methacrylate] (A1, A2), were synthesized with various incorporation ratios by reversible addition−fragmentation chain transfer (RAFT) polymerization. Dramatically different behavior was observed depending on the level of incorporation of the supramolecular units. At high loadings of A2 (6% SHB incorporation), intramolecular chain collapse is favored, resulting in the formation of well-defined polymer nanoparticles, which were characterized by scanning force microscopy (SFM), dynamic light scattering (DLS), and viscosity studies. In contrast, analysis of copolymer A1 (1% SHB incorporation) revealed that chain collapse occurred primarily through intermolecular interactions leading to large aggregates.
Original languageEnglish
Pages (from-to)6413-6418
Number of pages6
JournalMacromolecules
Volume41
Issue number17
DOIs
Publication statusPublished - 2008

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Hydrogen bonds
Nanoparticles
Polymers
Copolymers
Methacrylates
Polymethyl Methacrylate
Dynamic light scattering
Polymethyl methacrylates
Atomic force microscopy
Polymerization
Viscosity

Keywords

  • IR-99608

Cite this

Seo, Myungeun ; Beck, Benjamin J. ; Paulusse, Jos Marie Johannes ; Hawker, Craig J. ; Kim, Sang Youl. / Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains. In: Macromolecules. 2008 ; Vol. 41, No. 17. pp. 6413-6418.
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title = "Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains",
abstract = "Novel polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by noncovalent cross-linking of dendritic self-complementary hydrogen-bonding units (SHB). Random copolymers containing SHB units, poly[(methyl methacrylate)-r-2-((3,5-bis(4-carbamoyl-3-(trifluoromethyl)phenoxy)benzyloxy)carbonylamino)ethyl methacrylate] (A1, A2), were synthesized with various incorporation ratios by reversible addition−fragmentation chain transfer (RAFT) polymerization. Dramatically different behavior was observed depending on the level of incorporation of the supramolecular units. At high loadings of A2 (6{\%} SHB incorporation), intramolecular chain collapse is favored, resulting in the formation of well-defined polymer nanoparticles, which were characterized by scanning force microscopy (SFM), dynamic light scattering (DLS), and viscosity studies. In contrast, analysis of copolymer A1 (1{\%} SHB incorporation) revealed that chain collapse occurred primarily through intermolecular interactions leading to large aggregates.",
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Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains. / Seo, Myungeun; Beck, Benjamin J.; Paulusse, Jos Marie Johannes; Hawker, Craig J.; Kim, Sang Youl.

In: Macromolecules, Vol. 41, No. 17, 2008, p. 6413-6418.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains

AU - Seo, Myungeun

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AU - Paulusse, Jos Marie Johannes

AU - Hawker, Craig J.

AU - Kim, Sang Youl

PY - 2008

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N2 - Novel polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by noncovalent cross-linking of dendritic self-complementary hydrogen-bonding units (SHB). Random copolymers containing SHB units, poly[(methyl methacrylate)-r-2-((3,5-bis(4-carbamoyl-3-(trifluoromethyl)phenoxy)benzyloxy)carbonylamino)ethyl methacrylate] (A1, A2), were synthesized with various incorporation ratios by reversible addition−fragmentation chain transfer (RAFT) polymerization. Dramatically different behavior was observed depending on the level of incorporation of the supramolecular units. At high loadings of A2 (6% SHB incorporation), intramolecular chain collapse is favored, resulting in the formation of well-defined polymer nanoparticles, which were characterized by scanning force microscopy (SFM), dynamic light scattering (DLS), and viscosity studies. In contrast, analysis of copolymer A1 (1% SHB incorporation) revealed that chain collapse occurred primarily through intermolecular interactions leading to large aggregates.

AB - Novel polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by noncovalent cross-linking of dendritic self-complementary hydrogen-bonding units (SHB). Random copolymers containing SHB units, poly[(methyl methacrylate)-r-2-((3,5-bis(4-carbamoyl-3-(trifluoromethyl)phenoxy)benzyloxy)carbonylamino)ethyl methacrylate] (A1, A2), were synthesized with various incorporation ratios by reversible addition−fragmentation chain transfer (RAFT) polymerization. Dramatically different behavior was observed depending on the level of incorporation of the supramolecular units. At high loadings of A2 (6% SHB incorporation), intramolecular chain collapse is favored, resulting in the formation of well-defined polymer nanoparticles, which were characterized by scanning force microscopy (SFM), dynamic light scattering (DLS), and viscosity studies. In contrast, analysis of copolymer A1 (1% SHB incorporation) revealed that chain collapse occurred primarily through intermolecular interactions leading to large aggregates.

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